|2-(N-(5-溴-4-氟-2-甲基苯基)氨磺酰基)-5-(3,5-二氯苯磺酰氨基)苯甲酸甲酯|CsnPharm

CAS No.: 2275619-53-7

Methyl 2-(N-(5-bromo-4-fluoro-2-methylphenyl)sulfamoyl)-5-(3,5-dichlorophenylsulfonamido)benzoate Catalog No. CSN23882

Synonyms: Methyl 2-(N-(5-bromo-4-fluoro-2-methylphenyl)sulfamoyl)-5-(3,5-dichlorophenylsulfonamido)benzoate

DL-800 is an allosteric and selective SIRT6 activator with EC50 of 10.3μM.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述SIRT6, responsible for deacetylation of histone H3 N^ε-acetyl-lysines 9 (H3K9ac) and 56 (H3K56ac), is a tumor suppressor which has frequently been found to have low expression in various cancers. MDL-800 is a selective SIRT6 activator. It increased the deacetylase activity of SIRT6 by up to 22-fold and led to a global decrease in H3K9ac and H3K56ac levels in human hepatocellular carcinoma (HCC) cells. Also, it inhibited the proliferation of HCC cells via SIRT6-driven cell-cycle arrest and was effective in a tumor xenograft model.
作用机制MDL-800 can bind to an allosteric site of SIRT6 to increase its activity.
动物研究
剂量
Mice: 50 mg/kg - 150 mg/kg^[1] (i.p.)

给药途径
i.p.
参考文献

动物研究
剂量	Mice: 50 mg/kg - 150 mg/kg^[1] (i.p.)
给药途径	i.p.

[1] Huang Z, Zhao J, Deng W, et al. Identification of a cellularly active SIRT6 allosteric activator. Nat Chem Biol. 2018;14(12):1118-1126

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.5967 mL
- 7.9834 mL
- 15.9668 mL
- 5 mM
- 0.3193 mL
- 1.5967 mL
- 3.1934 mL
- 10 mM
- 0.1597 mL
- 0.7983 mL
- 1.5967 mL

技术信息

CAS号

2275619-53-7

储存条件

粉末: Keep in dark place,Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H16BrCl2FN2O6S2

运输

蓝冰

分子量

626.30

别名

Methyl 2-(N-(5-bromo-4-fluoro-2-methylphenyl)sulfamoyl)-5-(3,5-dichlorophenylsulfonamido)benzoate

溶解度

DMSO	125.0 mg/mL (199.6 mM)
Water	insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Methyl 2-(N-(5-bromo-4-fluoro-2-methylphenyl)sulfamoyl)-5-(3,5-dichlorophenylsulfonamido)benzoate Catalog No. CSN23882

靶点选择性

请登录您的专属账户

确认信息