|(1S,2R)-2-(氨甲基)-N,N-二乙基-1-苯基环丙烷甲酰胺盐酸盐|CsnPharm

CAS No.: 175131-60-9

Milnacipran ((1S-cis) HCl)/盐酸左旋米那普仑 Catalog No. CSN17228

Synonyms: Levomilnacipran hydrochloride;F-2695 hydrochloride;Levomilnacipran HCl

(1S-cis)-Milnacipran HCl inhibits serotonin-norepinephrine reuptake and is used for the treatment of fibromyalgia.

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技术信息

生物活性

描述Major depressive disorder (MDD) is a debilitating disease that is characterized by depressed mood, diminished interests, impaired cognitive function and vegetative symptoms, such as disturbed sleep or appetite^[3]. (1S-cis)-Milnacipran Hydrochloride is the latest antidepressants approved for the treatment of MDD. It acts through an increased serotonergic activity in the central nervous system by inhibiting the reuptake of serotonin (5-HT). In addition to the SSRI activity, (1S-cis)-Milnacipran Hydrochloride is also a norepinephrine reuptake inhibitor^[4]. In seven randomised, double-blind clinical trials, levomilnacipran is generally more effective than placebo for the treatment of MDD in the short-term. Preliminary evidence suggests that levomilnacipran extended release may be effective in improving not only depressive symptoms but also symptoms related to functioning (social life, work, and family life)^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.5360 mL
- 17.6798 mL
- 35.3596 mL
- 5 mM
- 0.7072 mL
- 3.5360 mL
- 7.0719 mL
- 10 mM
- 0.3536 mL
- 1.7680 mL
- 3.5360 mL

技术信息

CAS号

175131-60-9

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H23ClN2O

运输

蓝冰

分子量

282.81

别名

Levomilnacipran hydrochloride;F-2695 hydrochloride;Levomilnacipran HCl;F-2695 HCl;Levomilnacipran (hydrochloride);(1S-cis)-Milnacipran;F-2695;Levomilnacipran;Brand name: Fetzima

溶解度

DMSO	57.0 mg/mL (201.5 mM)

动物实验配方

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Milnacipran ((1S-cis) HCl)/盐酸左旋米那普仑 Catalog No. CSN17228

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