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CAS No.: 1644342-14-2

ML-792 Catalog No. CSN20617

Synonyms: ML-792

ML-792 is a mechanism-based SUMO-activating enzyme (SAE) inhibitor with nanomolar potency in cellular assays, which selectively blocks SAE enzyme activity and total SUMOylation, thus decreasing cancer cell proliferation.

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400-920-2911

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技术信息

生物活性

描述Small ubiquitin-like modifier (SUMO) family proteins regulate target-protein functions by post-translational modification in diverse biological signals in the cell, including DNA repair, nuclear transport, gene expression and so on. SUMO activating enzyme E (SAE) catalyzes the condensation between the SUMO C-terminal carboxylate and ATP to form a SUMO–AMP conjugate that subsequently reacts with the catalytic Cys residue of SAE to form a SUMO~SAE thioester conjugate^[2]. ML-792 is a SAE inhibitor that potently and selectively blocks SAE enzyme activity and total SUMOylation, thus decreasing cancer cell proliferation^[3].
参考文献

[1] He X, Riceberg J, et al. Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor. Nat Chem Biol. 2017 Sep 11.
[2] Zhao B, Villhauer EB, Bhuripanyo K, Kiyokawa H, Schindelin H, Yin J. SUMO-mimicking peptides inhibiting protein SUMOylation. Chembiochem. 2014 Dec 15;15(18):2662-6. doi: 10.1002/cbic.201402472. Epub 2014 Nov 20. PMID: 25412743; PMCID: PMC4643655.
[3] He X, Riceberg J, Soucy T, Koenig E, Minissale J, Gallery M, Bernard H, Yang X, Liao H, Rabino C, Shah P, Xega K, Yan ZH, Sintchak M, Bradley J, Xu H, Duffey M, England D, Mizutani H, Hu Z, Guo J, Chau R, Dick LR, Brownell JE, Newcomb J, Langston S, Lightcap ES, Bence N, Pulukuri SM. Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor. Nat Chem Biol. 2017 Nov;13(11):1164-1171. doi: 10.1038/nchembio.2463. Epub 2017 Sep 11. PMID: 28892090.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.8135 mL
- 9.0676 mL
- 18.1352 mL
- 5 mM
- 0.3627 mL
- 1.8135 mL
- 3.6270 mL
- 10 mM
- 0.1814 mL
- 0.9068 mL
- 1.8135 mL

技术信息

CAS号

1644342-14-2

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H23BrN6O5S

运输

蓝冰

分子量

551.41

别名

ML-792

溶解度

DMSO	420.0 mg/mL (761.7 mM)
Water	insoluble

动物实验配方

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ML-792 Catalog No. CSN20617

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