|2-乙酰基吩噻嗪|CsnPharm

CAS No.: 6631-94-3

ML171/2-乙酰基吩噻嗪 Catalog No. CSN21291

Synonyms: 2-Acetylphenothiazine;2-APT;NSC 57951

ML171 is a novel and selective NOX1 inhibitor with IC50 value of 0.25 μM for blocking NOX1-dependent ROS generation in a HEK293-NOX1 recombinant cell system.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述ML171 is a selective Nox1 inhibitor with 0.129μM and 0.25μM for blocking ROS production by NOX1 in HT29 cells and HEK293 cells, respectively. Treatment with 10μM ML171 for 1h significantly blocked ROS-dependent formation of ECM-degrading invadopodia in DLD1 cells. Inhibition of Nox1 by ML171 preserves beta cell function as ML171 at concentration of 10μM could reduce intracellular ROS induced by cytokine, preserve glucose-stimulated insulin secretion abolished by cytokine exposure, and protect beta cells from ROS-mediated dysfunction. Administration of 2.5nmol ML171 twice per week for 4 weeks to DEN-challenged mice blocked HCC development due to blocking chronic inflammation in the tumor bed. ML171 does not scavenge ROS generated by xanthine oxidase activity.
动物研究
剂量
Rat: 100 µg/Kg^[2] (i.v.) Mice: 60 mg/kg^[3] (i.p.)

给药途径
i.v., i.p.
参考文献

动物研究
剂量	Rat: 100 µg/Kg^[2] (i.v.) Mice: 60 mg/kg^[3] (i.p.)
给药途径	i.v., i.p.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.1440 mL
- 20.7202 mL
- 41.4405 mL
- 5 mM
- 0.8288 mL
- 4.1440 mL
- 8.2881 mL
- 10 mM
- 0.4144 mL
- 2.0720 mL
- 4.1440 mL

技术信息

CAS号

6631-94-3

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C14H11NOS

运输

蓝冰

分子量

241.31

别名

2-Acetylphenothiazine;2-APT;NSC 57951;NSC 169669

溶解度

DMSO	48.0 mg/mL (198.9 mM)

动物实验配方

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