CAS No.: 1443118-44-2
ML337 Catalog No. CSN22978
ML 337 is a selective negative allosteric modulator of mGlu3 with IC50 of 593 nM.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT02219685 Hepatitis C Virus Infection Phase 2 Completed - United States, Massachusetts ... more >> Boston, Massachusetts, United States Collapse << NCT02301936 Hepatitis C Virus Infection Phase 2 Completed - United States, Maryland ... more >> Lutherville, Maryland, United States Collapse << NCT02301936 - - Completed - - - 更多
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1443118-44-2 | 储存条件 |
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| 分子式 | C21H20FNO3 | 运输 | 蓝冰 | |
| 分子量 | 353.39 | 别名 |
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
|---|
| NCT02219685 | Hepatitis C Virus Infection | Phase 2 | Completed | - | United States, Massachusetts ... more >> Boston, Massachusetts, United States Collapse << |
| NCT02301936 | Hepatitis C Virus Infection | Phase 2 | Completed | - | United States, Maryland ... more >> Lutherville, Maryland, United States Collapse << |
| NCT02301936 | - | - | Completed | - | - |
| NCT01791205 | - | - | Completed | - | Italy ... more >> Reggio Calabria, Calabria, Italy, 89133 Napoli, Campania, Italy, 80131 Telese Terme, Campania, Italy, 82037 Bologna, Emilia-Romagna, Italy, 40138 Roma, Lazio, Italy, 00133 Roma, Lazio, Italy, 00152 Roma, Lazio, Italy, 00161 Roma, Lazio, Italy, 00189 Legnano, Lombardia, Italy, 20025 Milano, Lombardia, Italy, 20157 Milano, Lombardia, Italy, 20162 Monza, Lombardia, Italy, 20052 Pavia, Lombardia, Italy, 27100 Ancona, Marche, Italy, 60020 Jesi, Marche, Italy, 60035 Torino, Piemonte, Italy, 10126 Torino, Piemonte, Italy, 10128 Bari, Puglia, Italy, 70124 Martina Franca, Puglia, Italy, 74015 Sassari, Sardegna, Italy, 07100 Firenze, Toscana, Italy, 50139 Pisa, Toscana, Italy, 56100 Prato, Toscana, Italy, 59100 Siena, Toscana, Italy, 53100 Perugia, Umbria, Italy, 06122 Cona (Ferrara), Veneto, Italy, 44124 Padova, Veneto, Italy, 35128 Verona, Veneto, Italy, 37126 Collapse << |
| NCT00455013 | - | - | Completed | - | - |
| NCT03036839 | Chronic Hepatitis c | Phase 2 | Active, not recruiting | February 2019 | United States, Massachusetts ... more >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 United States, Michigan Henry Ford Health System Detroit, Michigan, United States, 48202 United States, New York James J. Peters Veterans Administration Medical Center Bronx, New York, United States, 10468 United States, Texas Methodist Healthcare Dallas - The Liver Institute Dallas, Texas, United States, 75203 Texas Liver Institute/American Research Corporation San Antonio, Texas, United States, 78215 United States, Washington University of Washington Seattle, Washington, United States, 98104 Belgium CUB Hopital Erasme Brussels, Belgium, 1070 Cliniques Universitaires UCL Saint-Luc Brussels, Belgium, 1200 Germany JWG-Universität Frankfurt Frankfurt, Germany, 60590 Universitatsklinikum Hamburg-Eppendorf Hamburg, Germany, 20246 Ifi Studien und Projekt GmbH Hamburg, Germany, 20251 University of Leipzig Leipzig, Germany, 04109 Italy IRCCS Ospedale Casa Sollievo Della Soferrenza San Giovanni Rotondo, Foggia, Italy, 71013 Ospedale Santa Maria Annunziata Antella, Italy, 50011 Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan, Italy, 20122 Azienda Ospedaliera Città della Salute e della Scienza di Torino Torino, Italy, 10126 Taiwan Changhua Christian Hospital Changhua, Taiwan, 500 Kaohsiung Medical University Hospital Kaohsiung, Taiwan, 807 Kaohsiung Chang Gung Memorial Hospital Kaohsiung, Taiwan, 83301 China Medical University Hospital Taichung, Taiwan, 40447 National Taiwan University Hospital Taipei, Taiwan, 10002 Collapse << |
| NCT02243800 | Rheumatoid Arthritis ... more >> Vitamin D Deficiency Collapse << | Phase 3 | Unknown | August 2016 | France ... more >> CHU Clermont-Ferrand Recruiting Clermont-Ferrand, France, 63003 Contact: Patrick LACARIN 04 73 75 11 95 placarin@chu-clermontferrand.fr Collapse << |
| NCT01791205 | - | - | Completed | - | - |
| NCT02219685 | - | - | Completed | - | - |
| NCT00455013 | Disorder Related to Renal Tran... more >>splantation Collapse << | Phase 2 | Completed | - | United States, California ... more >> Ucsf San Francisco, California, United States, 94143 United States, Colorado Denver Nephrology, Pc Denver, Colorado, United States, 80218 University Of Colorado Health Sciences Center Denver, Colorado, United States, 80262 United States, Georgia Medical College Of Georgia Augusta, Georgia, United States, 30912 United States, Illinois Northwestern University Feinberg School Of Medicine Chicago, Illinois, United States, 60611 United States, Michigan Henry Ford Hospital Detriot, Michigan, United States, 48202 United States, New York Albany Medical College Albany, New York, United States, 12208 United States, North Carolina Carolinas Medical Center Charlotte, North Carolina, United States, 28203 United States, Ohio University Of Cincinnati Cincinnati, Ohio, United States, 45267 Ohio State University Medical Center Columbus, Ohio, United States, 43210 United States, Tennessee Vanderbilt University Medical Center Nashville, Tennessee, United States, 37232 Italy Local Institution Bologna, Italy, 40138 Local Institution Brescia, Italy, 25123 Local Institution Padova, Italy, 35128 Local Institution Roma, Italy, 00168 Spain Local Institution Barcelona, Spain, 08907 Local Institution Sevilla, Spain, 41013 Collapse << |
| NCT01714817 | Lupus Nephritis | Phase 3 | Completed | - | - |
| NCT01714817 | - | - | Completed | - | - |
| NCT02868242 | Hepatitis C Virus Infection | Phase 2 | Active, not recruiting | February 2019 | Egypt ... more >> National Cancer Institute, Cairo University Cairo, Egypt Collapse << |
| NCT01987453 | HCV Infection | Phase 2 | Completed | - | - |
| NCT02487030 | Hepatitis C Virus Infection | Phase 3 | Completed | - | Egypt ... more >> Cairo, Egypt, 11559 Cairo, Egypt, 11796 Mansourah, Egypt Shibin Al Kawm, Egypt Collapse << |
| NCT01938378 | Adverse Effects in the Therape... more >>utic Use of Plasma Substitutes Collapse << | Phase 4 | Recruiting | December 2020 | United States, Alabama ... more >> Octapharma Research Site Recruiting Birmingham, Alabama, United States, 35233 United States, Georgia Octapharma Research Site Recruiting Atlanta, Georgia, United States, 30322 Contact: michael United States, Louisiana Octapharma Research Site Recruiting New Orleans, Louisiana, United States, 70118 United States, Minnesota Octapharma Research Site Recruiting Minneapolis, Minnesota, United States, 55455 United States, Missouri Octapharma Research Site Recruiting Saint Louis, Missouri, United States, 63130 United States, North Carolina Octapharma Research Site Recruiting Durham, North Carolina, United States, 27710 Collapse << |
| NCT02487030 | - | - | Completed | - | - |
| NCT03042520 | - | - | Recruiting | September 2022 | Korea, Democratic People's Rep... more >>ublic of Korea University Ansan Hospital Recruiting Ansan, Korea, Democratic People's Republic of Contact: Hyung Joon Yim Asan Medical Center Recruiting Asan, Korea, Democratic People's Republic of Contact: Young-Suk Lim Soon Chun Hyang University Hospital Bucheon. Recruiting Bucheon, Korea, Democratic People's Republic of Contact: Young Seok Kim Dong-A University Hospital Recruiting Busan, Korea, Democratic People's Republic of Contact: Sang-Young Han Inje University Busan Paik Hospital Recruiting Busan, Korea, Democratic People's Republic of Contact: Youn-Jae Lee Kyungpook National University Hospital Recruiting Daegu, Korea, Democratic People's Republic of Contact: Won Young Tak Gachon University Gil Hospital Recruiting Incheon, Korea, Democratic People's Republic of Contact: Ju-Hyun Kim Pusan National University Hospital Recruiting Pusan, Korea, Democratic People's Republic of Contact: Heo Jeong Korea University Guro Hospital Recruiting Seoul, Korea, Democratic People's Republic of Contact: Yoon Jun Kim Samsung Medical Center Recruiting Seoul, Korea, Democratic People's Republic of Contact: Seung Woon Paik Seoul National University Bundang Hosptial Recruiting Seoul, Korea, Democratic People's Republic of Contact: Sook-Hyang Jeong Seoul National University Hospital Recruiting Seoul, Korea, Democratic People's Republic of Contact: Kwan Soo Byun Seoul St. Mary's Hospital Recruiting Seoul, Korea, Democratic People's Republic of Contact: Seung-Kew Yoon Severance Hospital Recruiting Seoul, Korea, Democratic People's Republic of Contact: Sang Hoon Ahn Korea, Republic of Gangnam Severance Hospital Recruiting Seoul, Korea, Republic of Contact: Kwan Sik Lee Taiwan Changhua Christian Hospital Recruiting Changhua, Taiwan Contact: Yu-Chun Hsu Kaohsiung Chang Gung Memorial Hospital Recruiting Kaohsiung, Taiwan Contact: Tsung-Hui Hu Kaoshiung Medical University Hospital Recruiting Kaoshiung City, Taiwan Contact: Wan-Long Chuang 0975-356064 waloch@kmu.edu.tw Keelung Chang Gung Memorial Hospital Recruiting Keelung, Taiwan Contact: Rong-Nan Chien China Medical University Recruiting Taichung, Taiwan Contact: Cheng-Yuan Peng Chi Mei Liouying Hospital Recruiting Tainan, Taiwan Contact: Chih-Chou Chen MacKay Memorial Hospital Recruiting Taipei, Taiwan Contact: Horng-Yuan Wang National Cheng Kung University Hospital Recruiting Taipei, Taiwan Contact: Ting-Tsung Chang National Taiwan University Hospital Recruiting Taipei, Taiwan Contact: Jia-Horng Kao Taipei Veterans General Hospital Recruiting Taipei, Taiwan Contact: Chi-Jen Chu Linkou Chang Gung Memorial Hospital Recruiting Taoyuan, Taiwan Contact: I-Shyan Sheen Collapse << |
| NCT02740335 | Significant Bleeding Risk | Phase 3 | Recruiting | June 2021 | - |
| NCT02650024 | Hepatitis C H... more >>uman Immunodeficiency Virus Collapse << | Phase 4 | Recruiting | July 2020 | United States, California ... more >> Ucsd Hnrp Recruiting San Diego, California, United States, 92103 Contact: Melanie Crescini, B.S. 619-543-5016 mscrescini@ucsd.edu Collapse << |
| NCT01726517 | Chronic Hepatitis C Virus | Phase 2 | Completed | - | United States, Texas ... more >> San Antonio, Texas, United States, 78215 Collapse << |
| NCT01726517 | - | - | Completed | - | - |
| NCT02808715 | - | - | Completed | - | - |
| NCT02021656 | Chronic HCV Infection | Phase 3 | Completed | - | - |
| NCT02472886 | - | - | Completed | - | - |
| NCT02452944 | - | - | Completed | - | - |
| NCT02472886 | Hepatitis C Virus Infection | Phase 3 | Completed | - | Estonia ... more >> Tallinn, Estonia, 10167 Tartu, Estonia, 51014 Russian Federation Ekaterinburg, Russian Federation, 620102 Krasnoyarsk, Russian Federation, 660049 Moscow, Russian Federation, 105275 Moscow, Russian Federation, 107014 Moscow, Russian Federation, 111123 Moscow, Russian Federation, 115446 Moscow, Russian Federation, 117593 Moscow, Russian Federation, 119435 Moscow, Russian Federation, 119991 Moscow, Russian Federation, 125367 Moscow, Russian Federation, 127015 Moscow, Russian Federation, 129090 Moscow, Russian Federation, 129110 Samara, Russian Federation, 443063 St. Petersburg, Russian Federation, 190103 St.petersburg, Russian Federation, 194044 Stavropol, Russian Federation, 355017 Tyumen, Russian Federation, 625026 Collapse << |
| NCT02600351 | Hepatitis C Virus Infection | Phase 3 | Terminated(Due to lack of feas... more >>ibility of enrolling participants, the study was terminated early.) Collapse << | - | - |
| NCT02452944 | Bladder Cancer | Not Applicable | Completed | - | - |
| NCT01987453 | - | - | Completed | - | - |
| NCT02457611 | Hepatitis C Infection With HIV... more >> Co-Infection Collapse << | Phase 2 | Completed | - | Germany ... more >> Berlin, Germany Bonn, Germany Frankfurt am Main, Germany United Kingdom London, United Kingdom Collapse << |
| NCT02600351 | - | - | Terminated(Due to lack of feas... more >>ibility of enrolling participants, the study was terminated early.) Collapse << | - | - |
| NCT02350569 | Hepatitis C Virus Infection | Phase 2 | Completed | - | United States, California ... more >> San Francisco, California, United States United States, Illinois Chicago, Illinois, United States United States, Louisiana New Orleans, Louisiana, United States United States, Michigan Detroit, Michigan, United States United States, New York New York, New York, United States United States, Texas Dallas, Texas, United States Collapse << |
| NCT02350569 | - | - | Completed | - | - |
| NCT02226549 | - | - | Completed | - | - |
| NCT01938430 | Chronic HCV Infection | Phase 2 | Completed | - | - |
| NCT02457611 | - | - | Completed | - | - |
| NCT02010255 | Chronic HCV Infection | Phase 2 | Completed | - | - |
| NCT02226549 | Hepatitis C Virus Infection | Phase 2 | Completed | - | United States, Texas ... more >> San Antonio, Texas, United States Collapse << |
| NCT01701401 | Chronic Hepatitis C Virus | Phase 3 | Completed | - | - |
| NCT01768286 | Chronic Hepatitis C Virus | Phase 3 | Completed | - | - |
| NCT02010255 | - | - | Completed | - | - |
| NCT01826981 | - | - | Completed | - | - |
| NCT01851330 | Chronic Hepatitis C Virus | Phase 3 | Completed | - | - |
| NCT01768286 | - | - | Completed | - | - |
| NCT02738333 | Hepatitis C Virus Infection | Phase 3 | Completed | - | Japan ... more >> Bunkyo, Japan Chiba, Japan Chuo City, Japan Ehime, Japan Fukuoka, Japan Fukuyama, Japan Gifu, Japan Ibaragi, Japan Ikeda, Japan Iruma-gun, Japan Itabashi, Japan Izunokuni, Japan Kagoshima, Japan Kashihara, Japan Kitakyushu, Japan Kumamoto, Japan Kyoto, Japan Maebashi, Japan Matsumoto, Japan Morioka, Japan Musashino, Japan Nagasaki, Japan Nagoya, Japan Nishinomiya, Japan Ogaki City, Japan Okayama, Japan Omura, Japan Osaka, Japan Sagamihara, Japan Saga, Japan Sapporo, Japan Sendai, Japan Suita, Japan Takamatsu, Japan Ube, Japan Yamagata, Japan Yufu, Japan Collapse << |
| NCT01851330 | - | - | Completed | - | - |
| NCT02738333 | - | - | Completed | - | - |
| NCT01984294 | Chronic HCV Infection | Phase 2 | Completed | - | United States, Texas ... more >> San Antonio, Texas, United States, 78215 Collapse << |
| NCT01938430 | - | - | Completed | - | - |
| NCT01984294 | - | - | Completed | - | - |
| NCT02613871 | Hepatitis C Virus Infection | Phase 3 | Completed | - | Taiwan ... more >> Changhua, Taiwan Chiayi City, Taiwan Kaohsiung City, Taiwan Kaohsiung, Taiwan Keelung, Taiwan Taichung, Taiwan Tainan City, Taiwan Tainan, Taiwan Taipei City, Taiwan Taipei, Taiwan Taoyuan, Taiwan Collapse << |
| NCT02613871 | - | - | Completed | - | - |
| NCT01826981 | Chronic Hepatitis C | Phase 2 | Completed | - | New Zealand ... more >> Auckland Clinical Studies Ltd. Auckland, New Zealand Christchurch Clinical Studies Trust Christchurch, New Zealand Collapse << |
| NCT03776292 | - | - | Recruiting | March 2019 | Egypt ... more >> Mansoura faculty of Medicine- Mansoura Urology and nephrology center Recruiting Mansourah, Dakahlia, Egypt Contact: Mohamed A Ghanem, A.Professor 00201067883998 mohamed.abdel_latif@yahoo.com Collapse << |
| NCT01924949 | Hepatitis C | Phase 2 | Completed | - | United States, Massachusetts ... more >> Boston, Massachusetts, United States Collapse << |
| NCT02081079 | Chronic Genotype 4 HCV ... more >> Chronic Genotype 5 HCV Collapse << | Phase 2 | Completed | - | France ... more >> Clermont Ferrand, France, 63003 Clichy, France, 92110 Limoges, France, 87042 Toulouse, France, 31059 Villejuif, France, 94800 Collapse << |
| NCT02081079 | - | - | Completed | - | - |
| NCT02202980 | Chronic Hepatitis C | Phase 2 | Completed | - | New Zealand ... more >> Auckland, New Zealand Christchurch, New Zealand Collapse << |
| NCT01701401 | - | - | Completed | - | - |
| NCT02251717 | Hepatitis C Virus Infection | Phase 2 | Completed | - | Austria ... more >> Wien, Austria France Marseille, France Paris, France Germany Hannover, Germany Italy Milan, Italy Collapse << |
| NCT02480387 | Treatment of Hepatitis C | Phase 2 | Completed | - | United States, California ... more >> Peter J. Ruane, MD, Inc. Los Angeles, California, United States, 90036 Collapse << |
| NCT01924949 | - | - | Completed | - | - |
| NCT02251717 | - | - | Completed | - | - |
| NCT02413593 | Hepatitis C Virus Infection | Phase 2 | Completed | - | Canada, Alberta ... more >> Calgary, Alberta, Canada, T2N 4Z6 Edmonton, Alberta, Canada, T5H 4B9 Edmonton, Alberta, Canada, T6G 2B7 Canada, British Columbia Vancouver, British Columbia, Canada, V5Z 1H2 Vancouver, British Columbia, Canada, V5Z 1M9 Vancouver, British Columbia, Canada, V6Z 2K5 Canada, Ontario Brampton, Ontario, Canada, L6R 3J7 London, Ontario, Canada, N6A 5A5 Ottawa, Ontario, Canada, K1H 8L6 Toronto, Ontario, Canada, M5T 2S8 Toronto, Ontario, Canada, M6H 3M1 Vaughan, Ontario, Canada, L4L 4Y7 Canada, Quebec Montreal, Quebec, Canada, H2L 4P9 Montreal, Quebec, Canada, H2X 0A9 Canada Quebec, Canada, G1V 4G2 Collapse << |
| NCT01975675 | Chronic HCV Infection | Phase 3 | Completed | - | Japan ... more >> Ichikawa, Chiba, Japan, 272-8516 Kurume, Fukuoka, Japan, 830-0011 Ogaki, Gifu, Japan, 503-0864 Sapporo, Hokkaido, Japan, 060-8648 Nishinomiya, Hyogo, Japan, 663-8501 Matsumoto, Nagano, Japan, 390-8621 Omura, Nagasaki, Japan, 856-8562 Suita, Osaka, Japan, 565-0871 Izunokuni, Shizuoka, Japan, 410-2295 Chiyoda-ku, Tokyo, Japan, 101-8643 Itabashi-ku, Tokyo, Japan, 173-8610 Musashino, Tokyo, Japan, 180-8610 Shinjuku, Tokyo, Japan, 162-8566 Kofu, Yamanashi, Japan, 400-0027 Akita, Japan, 010-0933 Chiba, Japan, 260-0856 Gifu, Japan, 500-8513 Okayama, Japan, 700-8558 Yamagata, Japan, 990-9585 Collapse << |
| NCT02202980 | - | - | Completed | - | - |
| NCT02869763 | Alcohol Consumption ... more >> Healthy Collapse << | Not Applicable | Completed | - | Spain ... more >> Parc Salut Mar Barcelona, Spain, 08003 Collapse << |
| NCT01975675 | - | - | Completed | - | - |
| NCT01965535 | HCV Infection | Phase 2 | Completed | - | France ... more >> Clermont Ferrand, France, 63003 Clichy, France, 92110 Creteil, France, 94000 Grenoble, France, 38043 Lille, France, 57037 Limoges, France, 87042 Lyon, France, 69317 Marseille, France, 13285 Montpelier, France, 34295 Nancy, France, 54500 Nice, France, 06202 Paris, France, 75012 Paris, France, 75013 Paris, France, 75014 Paris, France, 75020 Pessac, France, 33604 Rennes, France, 35033 Strasbourg, France, 67091 Toulouse, France, 31059 Collapse << |
| NCT02073656 | - | - | Completed | - | - |
| NCT02413593 | - | - | Completed | - | - |
| NCT01965535 | - | - | Completed | - | - |
| NCT02073656 | Hepatitis C Virus ... more >> HIV Collapse << | Phase 3 | Completed | - | - |
