|ML753286游离态|CsnPharm

CAS No.: 1699720-89-2

ML753286/ML753286游离态 Catalog No. CSN20009

Synonyms: N/A

ML753286 is a potent inhibitor for BCRP, but not for P-glycoprotein (P-gp), organic anion-transporting polypeptide (OATP), or major cytochrome P450s (CYPs).

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述ML753286 is a potent inhibitor for BCRP, but not for P-glycoprotein (P-gp), organic anion-transporting polypeptide (OATP), or major cytochrome P450s (CYPs). It has high permeability, but is not an efflux transporter substrate. ML753286 has low to medium clearance in rodent and human liver S9 fractions, and is stable in plasma cross species. Bcrp inhibition affects oral absorption and clearance of sulfasalazine in rodents.
参考文献

[1] Liao M, Chuang BC, et al. Preclinical Absorption, Distribution, Metabolism, Excretion, and Pharmacokinetics of A Novel Selective Inhibitor of Breast Cancer Resistance Protein (BCRP). Xenobiotica. 2017 May 9:1-39.
[2] Li Y, Woo J, Chmielecki J, et al. Synthesis of a new inhibitor of breast cancer resistance protein with significantly improved pharmacokinetic profiles. Bioorg Med Chem Lett. 2016 Jan 15;26(2):551-5.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8135 mL
- 14.0674 mL
- 28.1349 mL
- 5 mM
- 0.5627 mL
- 2.8135 mL
- 5.6270 mL
- 10 mM
- 0.2813 mL
- 1.4067 mL
- 2.8135 mL

技术信息

CAS号	1699720-89-2	储存条件	粉末液体 -20°C:3-6 月 -80°C:12月
分子式	C20H25N3O3	运输	蓝冰
分子量	355.43	别名	N/A

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

ML753286/ML753286游离态 Catalog No. CSN20009

靶点选择性

请登录您的专属账户

确认信息