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CAS No.: 92831-11-3

MN-64 Catalog No. CSN16905

Synonyms: MN-64

MN-64 is an inhibitor of tankyrases, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.

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400-920-2911

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Tankyrases, belonging to the diphtheria toxin-like ADP-ribosyltransferase (ARTD) enzyme family also known as poly ADP ribose polymerases (PARPs), are mainly found in nuclear pore complexes, the cytoplasm, mitotic centrosomes, and the Golgi apparatus and are involved in many critical cellular functions. MN-64 is a potent TNKS1 and TNKS2 inhibitor with IC₅₀s of 6 nM, 72 nM, respectively. MN-64 effectively inhibits Wnt/β-catenin at 1 μM, and blocks SuperTopFlash (STF) luciferase activity at 200 nM^[2].
作用机制The increased potency of MN-64 results from the efficient hydrophobic interactions with Pro1034 and Phe1035^[2].
参考文献

[1] Narwal M, Koivunen J, et al. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J Med Chem. 2013 Oct 24;56(20):7880-9.
[2] Narwal M, Koivunen J, Haikarainen T, et al. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J Med Chem. 2013;56(20):7880-7889

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.7833 mL
- 18.9166 mL
- 37.8331 mL
- 5 mM
- 0.7567 mL
- 3.7833 mL
- 7.5666 mL
- 10 mM
- 0.3783 mL
- 1.8917 mL
- 3.7833 mL

技术信息

CAS号

92831-11-3

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H16O2

运输

蓝冰

分子量

264.32

别名

MN-64

溶解度

DMSO	205.0 mg/mL (775.6 mM)
Water	insoluble

动物实验配方

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MN-64 Catalog No. CSN16905

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