生物活性

• 描述KRP-203 is a selective Sphingosine-1-phosphate receptor agonist that has been shown to reduce peripheral lymphocyte infiltration and to prolong survival in rat transplant models.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT01830010	Hematological Malignancies	Phase 1	Completed	-	France ... more >> Novartis Investigative Site Paris, France, 75010 Germany Novartis Investigative Site Regensburg, Bavaria, Germany, 93053 Novartis Investigative Site Freiburg, Germany, 79106 Novartis Investigative Site Hamburg, Germany, 20246 Novartis Investigative Site Jena, Germany, 07740 Novartis Investigative Site Koeln, Germany, 50937 Switzerland Novartis Investigative Site Basel, Switzerland, 4031 Novartis Investigative Site Zürich, Switzerland, 8091 Collapse <<
  NCT01375179	Ulcerative Colitis	Phase 2	Terminated	-	Belgium ... more >> Novartis Investigative Site Gent, Belgium, 9000 Novartis Investigative Site Leuven, Belgium, 3000 Germany Novartis Investigative Site Frankfurt am Main, Germany, 60318 Novartis Investigative Site Hamburg, Germany, 20148 Novartis Investigative Site Köln, Germany, 51103 Hungary Novartis Investigative Site Budapest, Hungary, 1083 Novartis Investigative Site Debrecen, Hungary, 4032 Sweden Novartis Investigative Site Stockholm, Sweden, 116 91 Novartis Investigative Site Stockholm, Sweden, SE-141 86 Novartis Investigative Site Uppsala, Sweden, 751 85 Switzerland Novartis Investigative Site Bern, Switzerland, 3010 Novartis Investigative Site Zurich, Switzerland, 8091 United Kingdom Novartis Investigative Site Oxford, Oxfordshire, United Kingdom, OX3 9DU Novartis Investigative Site Nottingham, United Kingdom, NG7 2UH Collapse <<
  NCT01294774	Subacute Cutaneous Lupus Eryth... more >>ematosus Collapse <<	Phase 2	Completed	-	Germany ... more >> Novartis Investigative Site Bochum, Germany, 44791 Novartis Investigative Site Bonn, Germany, 53105 Novartis Investigative Site Frankfurt am Main, Germany, 60596 Novartis Investigative Site Tuebingen, Germany, 72076 Greece Novartis Investigative Site Athens, GR, Greece, 161 21 Novartis Investigative Site Thessaloniki, GR, Greece, 546 29 Italy Novartis Investigative Site Genova, GE, Italy, 16132 Novartis Investigative Site Siena, SI, Italy, 53100 Collapse <<

• 参考文献

• [1] Poti F, Gualtieri F, et al. KRP-203, sphingosine 1-phosphate receptor type 1 agonist, ameliorates atherosclerosis in LDL-R-/- mice. Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1505-12.

  [2] Shimizu H, Takahashi M, et al. KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronic rejection in rat skin and heart allografts. Circulation. 2005 Jan 18;111(2):222-9.