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CAS No.: 2055397-88-9

MOZ-IN-2 Catalog No. CSN22468

Synonyms: Moz-in-2

MOZ-IN-2 is an inhibitor of protein MOZ, a member of histone acetyltransferases, with an IC50 of 125 μM.

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描述Histone acetyltransferase 1 (HAT1) is a type B histone acetyltransferase, regulating the acetylation of both histone and non-histone proteins. HAT1 modulates lysine succinylation on various proteins including histones and non-histones. HAT1 succinylates histone H3 on K122, contributing to epigenetic regulation and gene expression in cancer cells^[1].HAT1 is responsible for the cytosolic diacetylation of newly synthesized histone H4 on lysines 5 and 12, which accompanies replication-coupled chromatin assembly^[2]. MOZ (monocytic leukaemia zinc finger protein; also known as ZNF220 or MYST3) is a member of the MYST family of protein acetyltransferases^[3]. MOZ is one of the most important histone acetyltransferases (HATs) that has an effective role in gene expression. It is an important partner in chromosomal rearrangement that usually occurs in hematological malignancies such as leukemia^[4]. It functions as a quaternary complex with the bromodomain PHD finger protein 1 (BRPF1), the human Esa1-associated factor 6 homolog (hEAF6), and the inhibitor of growth 5 (ING5)^[5]. MOZ-TIF2 silences expression of the CDKN2A locus (p16(INK4a) and p19(ARF)), inhibits the triggering of senescence and enhances proliferation, providing conditions favorable to the development of leukemia^[6]. MOZ-IN-2 is an protein MOZ inhibitor(IC50 of 125 μM)^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.6855 mL
- 13.4274 mL
- 26.8548 mL
- 5 mM
- 0.5371 mL
- 2.6855 mL
- 5.3710 mL
- 10 mM
- 0.2685 mL
- 1.3427 mL
- 2.6855 mL

技术信息

CAS号

2055397-88-9

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H13FN4O3S

运输

蓝冰

分子量

372.37

别名

Moz-in-2

溶解度

DMSO	120.0 mg/mL (322.3 mM) warming

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