生物活性

• 描述Mutant IDH1 inhibitor is a potent mutant IDH1 R132H inhibitor with IC50 of < 72 nM.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT03564821	IDH1 Mutation Myeloid Neoplasm... more >>s Collapse <<	Phase 1	Not yet recruiting	July 31, 2024	United States, Massachusetts ... more >> Massachusetts General Hospital Not yet recruiting Boston, Massachusetts, United States, 02214 Contact: Amir T Fathi, MD    617-724-4000    afathi@partners.org    Principal Investigator: Amir T Fathi, MD Collapse <<
  NCT03127735	Leukemia, Myeloid, Acute	Phase 1	Active, not recruiting	October 11, 2019	United States, California ... more >> University of Southern California Keck School of Medicine Los Angeles, California, United States, 90033-9172 United States, Florida University of Florida-Gainesville Gainesville, Florida, United States, 32608 United States, Georgia Northside Hospital - Atlanta Atlanta, Georgia, United States, 30342 United States, Illinois Northwestern Memorial Hospital Chicago, Illinois, United States, 60611-2908 United States, New York Montefiore Medical Center Bronx, New York, United States, 10467-2490 Roswell Park Cancer Institute Buffalo, New York, United States, 14263-0001 Mount Sinai Medical Center New York, New York, United States, 10029 United States, North Carolina Wake Forest Baptist Health Winston-Salem, North Carolina, United States, 27157 United States, Ohio Ohio State University Columbus, Ohio, United States, 43210 United States, Pennsylvania University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Thomas Jefferson University Philadelphia, Pennsylvania, United States, 19107 United States, Texas University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Germany Universitätsklinikum Heidelberg Heidelberg, Baden-Württemberg, Germany, 69120 Klinikum rechts der Isar München, Bayern, Germany, 81675 Medizinische Hochschule Hannover (MHH) Hannover, Niedersachsen, Germany, 30625 Universitätsklinikum Essen Essen, Nordrhein-Westfalen, Germany, 45122 Universitätsklinikum Leipzig AöR Leipzig, Sachsen, Germany Universitätsklinikum Charite zu Berlin Berlin, Germany, 12200 Universitätsklinikum Hamburg Eppendorf (UKE) Hamburg, Germany, 20246 Collapse <<
  NCT03212274	Advanced Malignant Solid Neopl... more >>asm Glioblastoma IDH1 Gene Mutation IDH2 Gene Mutation Recurrent Cholangiocarcinoma Recurrent Glioma Recurrent Malignant Solid Neoplasm WHO Grade II Glioma WHO Grade III Glioma Collapse <<	Phase 2	Suspended(Other - null)	July 31, 2019	United States, California ... more >> University of California Davis Comprehensive Cancer Center Sacramento, California, United States, 95817 United States, Connecticut Smilow Cancer Center/Yale-New Haven Hospital New Haven, Connecticut, United States, 06510 Yale University New Haven, Connecticut, United States, 06520 United States, District of Columbia MedStar Georgetown University Hospital Washington, District of Columbia, United States, 20007 United States, Maryland Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland, United States, 21287 United States, Massachusetts Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States, 02114 Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 United States, Ohio Ohio State University Comprehensive Cancer Center Columbus, Ohio, United States, 43210 United States, Pennsylvania University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania, United States, 15232 United States, Texas M D Anderson Cancer Center Houston, Texas, United States, 77030 Collapse <<

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