N-Methylcytisine(NMC), a tricyclic quinolizidine alkaloid, exerts hypoglycaemic, analgesic and anti-inflammatory activities. Oral administration (1, 4 and 16 mg/kg) of NMC attenuated the DSS(dextran sulfate sodium)-induced clinical symptoms and pathological damage. In addition, NMC treatment significantly reduced myeloperoxidase activity and level of pro-inflammatory cytokines. NMC blocked the activation of NF-κB by inhibiting IκB and IKK phosphorylation[3]. N-methylcytisine is a selective ligand of nicotinic receptors of acetylcholine in the central nervous system and has a high affinity (Kd = 50 nM) to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia[4].
搜索
