CAS No.: 627034-85-9
NF449 octasodium Catalog No. CSN16004
Synonyms: NF449 (sodium salt);NF-449
NF449 is a potent purinergic receptor antagonist that displays high selectivity for P2X1 (IC50 values are 0.28, 0.69, 120, 1820, 47000 and > 300000 nM for rP2X1, rP2X1+5, rP2X2+3, rP2X3, rP2X2 and P2X4 receptors respectively). Provides antithrombotic protection in vivo. Also acts as a Gsα-selective antagonist.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Fleming A, Noda T, et al. Chemical modulators of autophagy as biological probes and potential therapeutics. Nat Chem Biol. 2011 Jan;7(1):9-17.
- [2] Hechler B, Magnenat S, et al. Inhibition of platelet functions and thrombosis through selective or nonselective inhibition of the platelet P2 receptors with increasing doses of NF449 [4,4',4'',4''' (carbonylbis(imino-5,1,3-benzenetriylbis-(carbonylimino)))tetrakis-benzene-1,3-disulfonic acid octasodium salt] . J Pharmacol Exp Ther. 2005 Jul;314(1):232-43.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 627034-85-9 | 储存条件 |
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| 分子式 | C41H24N6Na8O29S8 | 运输 | 蓝冰 | |
| 分子量 | 1505.09 | 别名 | NF449 (sodium salt);NF-449 |
