CAS No.: 1038915-64-8
Niraparib HCl Catalog No. CSN17415
Synonyms: MK-4827 hydrochloride;Niraparib HCl;Niraparib
MK-4827 HCl is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM, showing great activity in cancer cells with mutant BRCA-1 and BRCA-2, and is > 330-fold selective against PARP3, V-PARP and Tank1.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Bridges KA, Toniatti C, et al. Niraparib(MK-4827), a novel poly(ADP-Ribose) polymerase inhibitor, radiosensitizes human lung and breast cancer cells. Oncotarget. 2014 Jul 15;5(13):5076-86.
- [2] Jones P, Altamura S, et al. Discovery of 2-{4-[(3S)-piperidin-3-yl] phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. J Med Chem. 2009 Nov 26;52(22):7170-85.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1038915-64-8 | 储存条件 |
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| 分子式 | C19H21ClN4O | 运输 | 蓝冰 | |
| 分子量 | 356.85 | 别名 | MK-4827 hydrochloride;Niraparib HCl;Niraparib;Zejula |
