|1-苄基-3-己基胍盐酸盐|CsnPharm

CAS No.: 1172854-54-4

NS-3-008 HCl/1-苄基-3-己基胍盐酸盐 Catalog No. CSN25657

Synonyms: NS-3-008 HCl;NS-3-008

NS-3-008 is a novel transcriptional inhibitor of G0s2 with IC50 value of 2.25μM. It resulted in decreased levels of G0s2 and Ccl2 mRNA in the kidneys of wild-type 5/6Nx mice at dose of 5mg/kg.

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描述G₀/G₁ switch 2 (G0s2) may aggravate renal dysfunction in the context of CKD (chronic kidney disease) through mechanisms involving increased renal expression of the Clock gene making G0s2 a promising therapeutic target in the treatment of CKD. NS-3-008 HCl is an orally active G0s2 transcriptional inhibitor with an IC₅₀ of 2.25 μM. Treatment of wild-type 5/6Nx mice with NS-3-008 (5 mg/kg, P.O.) resulted in decreased levels of G0s2 and Ccl2 mRNA in the kidneys. Furthermore, the phosphorylation of Stat5 and p65 protein was decreased in wild-type 5/6Nx mice treated with NS-3-008, and serum urea nitrogen (SUN) concentrations and renal caspase 3/7 activity decreased as well. Finally, the F4/80-positive area and F4/80 protein levels were decreased in 5/6Nx mice treated with NS-3-008^[1].
作用机制NS-3-008 bound to Hsd17b4^[1].
参考文献

[1] Matsunaga N, Ikeda E, Kakimoto K, et al. Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease. EbioMedicine. 2016;13:262-273

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.7063 mL
- 18.5313 mL
- 37.0626 mL
- 5 mM
- 0.7413 mL
- 3.7063 mL
- 7.4125 mL
- 10 mM
- 0.3706 mL
- 1.8531 mL
- 3.7063 mL

技术信息

CAS号

1172854-54-4

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C14H24ClN3

运输

蓝冰

分子量

269.81

别名

NS-3-008 HCl;NS-3-008

溶解度

DMSO	120.0 mg/mL (444.8 mM) warming
Water	125.0 mg/mL (463.3 mM) warming

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