CAS No.: 1445790-55-5
NVR 3-778 Catalog No. CSN28778
Synonyms: K-89;NVR 3-378
NVR3-778 is a first-in-class capsid assembly modulators currently in phase II clinical trial for the treatment of HBV infection. It exhibited anti-HBV activity with IC50 value of 0.26 µM.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 参考文献
- [1] Yuen MF, Gane EJ, Kim DJ, Weilert F, Yuen Chan HL, Lalezari J, Hwang SG, Nguyen T, Flores O, Hartman G, Liaw S, Lenz O, Kakuda TN, Talloen W, Schwabe C, Klumpp K, Brown N. Antiviral Activity, Safety, and Pharmacokinetics of Capsid Assembly Modulator NVR 3-778 in Patients with Chronic HBV Infection. Gastroenterology. 2019 Apr;156(5):1392-1403.e7. doi: 10.1053/j.gastro.2018.12.023. Epub 2019 Jan 6. PMID: 30625297.
- [2] Lv K, Li W, Wu S, Geng Y, Wang A, Yang L, Huang M, Chowdhury K, Li Y, Liu M. Amino acid prodrugs of NVR3-778: Design, synthesis and anti-HBV activity. Bioorg Med Chem Lett. 2020 May 1;30(9):127103. doi: 10.1016/j.bmcl.2020.127103. Epub 2020 Mar 9. PMID: 32173194.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1445790-55-5 | 储存条件 |
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| 分子式 | C18H16F4N2O4S | 运输 | 蓝冰 | |
| 分子量 | 432.39 | 别名 | K-89;NVR 3-378 |
