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ODQ 99%+

货号：A222246 同义名： 1H-ODQ 产品仅供科研

ODQ is a selective and irreversible inhibitor of nitric oxide-sensitive guanylyl cyclase.

ODQ 化学结构 CAS号：41443-28-1
ODQ 化学结构
CAS号：41443-28-1
ODQ 3D分子结构
CAS号：41443-28-1
ODQ 化学结构 CAS号：41443-28-1
ODQ 3D分子结构 CAS号：41443-28-1
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ODQ 纯度/质量文件

货号：A222246 标准纯度：99%+
批次查询： 批次纯度:

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ODQ 生物活性

描述 Soluble guanylyl cyclase (sGC) is the principal enzyme in mediating the biological actions of nitric oxide. On activation, sGC converts guanosine triphosphate to guanosine 3',5'-cyclic monophosphate (cGMP), which mediates diverse physiological processes including vasodilation, platelet aggregation, and myocardial functions predominantly by acting on cGMP-dependent protein kinases[1].Impaired NO-sGC-cGMP signaling could lead to osteoblast apoptosis by mechanisms involving the oxidative-stress-induced shift of the redox state of the reduced heme to oxidized sGC, leading to diminished heme binding to the enzyme and rendering the sGC unresponsive to NO. Targeting oxidized sGC to enhance cGMP production could restore proliferation and differentiation of osteoblasts into osteocytes[2]. ODQ is a potent and selective sGC inhibitor. ODQ enhances the pro-apoptotic effects of Cisplatin in human mesothelioma cells. At 30 and 50 μM, ODQ causes significant induction of apoptosis in the NCI-H2452 cells, elevating apoptotic levels by 12 fold and 15 fold, respectively. At 10μM, a concentration below the threshold for induction of apoptosis by ODQ, ODQ in combination with Cisplatin enhanced (in fact, doubled) the pro-apoptotic effects of Cisplatin at 1 μM[3]. ODQ (2 mg/kg; i.p.) reduces the multiple organ injury and dysfunction caused by wall fragments of Gram-positive or Gram-negative bacteria in the anesthetized rat[4].

ODQ 参考文献

[1]Yuansheng Gao. Conventional and Unconventional Mechanisms for Soluble Guanylyl Cyclase Signaling. J Cardiovasc Pharmacol. 2016 May;67(5):367-72.

[2] Belay Tesfamariam,et al. Targeting heme-oxidized soluble guanylate cyclase to promote osteoblast function. Drug Discov Today. 2020 Feb;25(2):422-429.

[3] Ronald Fiscus, et al. ODQ, an inhibitor of soluble guanylyl cyclase (nitric oxide-activated enzyme), enhances the pro-apoptotic effects of cisplatin in human mesothelioma cells. Cancer Res May 1 2007 (67) (9 Supplement) LB-43.

[4] Zacharowski K, et al. The selective guanylate cyclase inhibitor ODQ reduces multiple organ injury in rodent models of Gram-positive and Gram-negative shock. Crit Care Med. 2001;29(8):1599-1608.

ODQ 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

5.34mL

1.07mL

0.53mL

26.72mL

5.34mL

2.67mL

53.43mL

10.69mL

5.34mL

ODQ 技术信息

CAS号41443-28-1
分子式C9H5N3O2
分子量187.155
别名 1H-ODQ
运输蓝冰
存储条件

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 105 mg/mL(561.03 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: ODQ | 41443-28-1 | sGC Inhibitor | GPCR/G Protein | Apoptosis | Guanylate Cyclase | Apoptosis | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | ODQ 纯度/质量文件 | ODQ 生物活性 | ODQ 参考文献 | ODQ 实验方案 | ODQ 技术信息

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