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硝酸奥昔康唑 /Oxiconazole nitrate 98%+

货号:A173419 同义名: Ro 13-8996;Oxiconazole (nitrate) 产品仅供科研

Oxiconazole is an antifungal medication.

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Type HazMat fee for 500 gram (Estimated)
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Limited Quantity USD 15-60
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Oxiconazole nitrate 化学结构 CAS号:64211-46-7
Oxiconazole nitrate 化学结构
CAS号:64211-46-7
Oxiconazole nitrate 3D分子结构
CAS号:64211-46-7
Oxiconazole nitrate 化学结构 CAS号:64211-46-7
Oxiconazole nitrate 3D分子结构 CAS号:64211-46-7
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Oxiconazole nitrate 纯度/质量文件

货号:A173419 标准纯度:98%+
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Oxiconazole nitrate 生物活性

描述 Oxiconazole nitrate is a broad spectrum antifungal which can inhibit the growth of T. tonsurans and T. rubrum with MIC90s of 0.25 and 0.5 μg/mL, respectively[1]. It acts by erogosterol biosynthesis inhibition, which causes lysis of the fungal cell membrane because of changes in both membrane integrity and fluidity and direct membrane damage of fungal cells[2]. Applied once daily for four weeks in the treatment of tinea pedis or for two weeks in the treatment of tinea corporis, tinea cruris, and tinea versicolor, 1% oxiconazole cream has produced mycologic and clinical cures in at least 80% of patients[3]. Oxiconazole showed a higher activity than that of econazole in Candida spp. and yeasts other than Candida[4].

Oxiconazole nitrate 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01519752 Tinea Pedis Phase 1 Completed - -

Oxiconazole nitrate 参考文献

[1]Shadomy S, Wang H, Shadomy HJ. Further in vitro studies with oxiconazole nitrate. Diagn Microbiol Infect Dis. 1988 Apr;9(4):231-7

[2]Ranpise HA, Gujar KN, Mathure D, Satpute PP, Awasthi R, Dua K, Madan JR. Skin Targeting of Oxiconazole Nitrate Loaded Nanostructured Lipid- Carrier Gel for Fungal Infections. Pharm Nanotechnol. 2018;6(3):192-200

[3]Jegasothy BV, Pakes GE. Oxiconazole nitrate: pharmacology, efficacy, and safety of a new imidazole antifungal agent. Clin Ther. 1991 Jan-Feb;13(1):126-41

[4]Pereiro MJ, Iglesias-Grobas A, Pérez JT. Comparación in vitro de la acción antifúngica del oxiconazol y el econazol frente a levaduras [In vitro comparison of antifungal activity of oxiconazole and econazole against yeast.]. Rev Iberoam Micol. 1998 Jun;15(2):75-7. Spanish

[5]Jegasothy BV, Pakes GE. Oxiconazole nitrate: pharmacology, efficacy, and safety of a new imidazole antifungal agent. Clin Ther. 1991 Jan-Feb;13(1):126-41

[6]Pereiro MJ, Iglesias-Grobas A, Pérez JT. Comparación in vitro de la acción antifúngica del oxiconazol y el econazol frente a levaduras [In vitro comparison of antifungal activity of oxiconazole and econazole against yeast.]. Rev Iberoam Micol. 1998 Jun;15(2):75-7. Spanish

Oxiconazole nitrate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.03mL

0.41mL

0.20mL

10.16mL

2.03mL

1.02mL

20.32mL

4.06mL

2.03mL

Oxiconazole nitrate 技术信息

CAS号64211-46-7
分子式C18H14Cl4N4O4
分子量492.14
别名 Ro 13-8996;Oxiconazole (nitrate)
运输蓝冰
存储条件

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 105 mg/mL(213.35 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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