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CAS No.: 185039-89-8
Synonyms: PD0166285
PD0166285 inhibits Wee1 and Chk1 at nanomolar concentrations and can hinder G2 checkpoint.
生物活性
实验方案
技术信息
CAS号 | 185039-89-8 | 储存条件 |
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分子式 | C26H27Cl2N5O2 | 运输 | 蓝冰 | |||||
分子量 | 512.43 | 别名 | PD0166285 | |||||
溶解度 |
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动物实验配方 |
Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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C6 cell | - | Function assay | - | Inhibition of C6 cell proliferation in sulforhodamine B assay, IC50=0.34 μM | 9703473 |
C6 cells | - | Function assay | - | Inhibition of PDGF-induced autophosphorylation of PDGF-R in C6 cells, IC50=5 nM | 9703473 |
HCT-8 | - | Function assay | - | Inhibitory activity against HCT-8 human colon adenocarcinoma cells was determined, IC50=0.42 μM | 10956222 |
HEK293 cells | - | Function assay | - | Binding affinity to human full-length His-tagged Myt1 kinase expressed in HEK293 cells by TR-FRET based binding assay, IC50=7.2 nM | 22770610 |
HT-29 | - | Function assay | - | Inhibitory activity against HT-29 human colon adenocarcinoma cells was determined, IC50=0.28 μM | 10956222 |
NIH3T3 cells | - | Function assay | - | Inhibition of PDGF-induced autophosphorylation of PDGF-R in NIH3T3 cells, IC50=1.8 nM | 9703473 |
SW-620 | - | Function assay | - | Inhibitory activity against SW-620 human colon adenocarcinoma cells was determined, IC50=0.27 μM | 10956222 |
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