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CAS No.: 898044-15-0
Synonyms: PF-03758309;PF-309
PF-3758309 is an inhbitor of PAKs with IC50 of 1.3 nM for PAK4, which inhbits tumor growth in HCT116, A549, M24met and other xenograft tumor models.
生物活性
靶点 | PAK4 IC50:1.3nM |
实验方案
技术信息
CAS号 | 898044-15-0 | 储存条件 |
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分子式 | C25H30N8OS | 运输 | 蓝冰 | |||||||
分子量 | 490.62 | 别名 | PF-03758309;PF-309 | |||||||
溶解度 |
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动物实验配方 |
Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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human MDA-MB-436 cells | - | Cytotoxic assay | 24-48 h | Cytotoxicity against human MDA-MB-436 cells assessed as reduction in cell viability after 24 to 48 hrs by Celltiter-glo luminescence assay, IC50=0.79 nM | 24432870 |
靶点 | Description | IC50 |
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PAK4 | IC50:1.3nM |
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