|苯甲基磺酰氟|CsnPharm

CAS No.: 329-98-6

苄基磺酰氟 Catalog No. CSN12741

Synonyms: 苯甲基磺酰氟;Phenylmethylsulfonyl fluoride;Benzylsulfonyl fluoride

PMSF is a non-selective serine/cysteine protease inhibitor, also blocks anandamide metabolism.

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技术信息

生物活性

描述Phenylmethanesulfonyl fluoride (PMSF) is an irreversible serine/cysteine protease inhibitor used in protein extraction experiment. It is also a putative inhibitor of phosphatidylinositol-specific phospholipase C, almost completely inhibited carbachol-stimulated inositol incorporation into phosphatidylinositol (PI) of longitudinal smooth muscle of guinea pig ileum, while it had no effect on potassium-stimulated inositol incorporation. PMSF (2 mM) inhibited carbachol-stimulated inositol phosphate accumulation in the presence of Li+ by only 15% - 19%^[3]. Mice receiving i.p. injections of PMSF exhibited cannabinoid effects that included antinociception, hypothermia and immobility with ED50 values of 86, 224 and 206 mg/kg, respectively. Spontaneous activity was reduced at doses greater than 100 mg/kg. On the other hand, pretreatment with an inactive dose of PMSF (30 mg/kg) potentiated the effects of anandamide on tail-flick response (antinociception), spontaneous activity and mobility by 5-, 10- and 8-fold, respectively. PMSF did not alter anandamide's hypothermic effects^[4]. PMSF inhibits the acylation of the inositol residue of GPI intermediates in bloodstream form T. brucei. PMSF inhihits the formntion of glycolipid C but does not inhibit fatty acid remodeling in vitro. PMSF inhihits GPI acylation and ethanolamine phosphatp addition in procyclic trypanosomes but not in Hela cells^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.7408 mL
- 28.7038 mL
- 57.4077 mL
- 5 mM
- 1.1482 mL
- 5.7408 mL
- 11.4815 mL
- 10 mM
- 0.5741 mL
- 2.8704 mL
- 5.7408 mL

技术信息

CAS号

329-98-6

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C7H7FO2S

运输

蓝冰

分子量

174.19

别名

苯甲基磺酰氟;Phenylmethylsulfonyl fluoride;Benzylsulfonyl fluoride

溶解度

DMSO	355.0 mg/mL (2038.0 mM)
Water	insoluble

动物实验配方

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苄基磺酰氟 Catalog No. CSN12741

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