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CAS No.: 63208-82-2

Pifithrin-α HBr Catalog No. CSN16583

Synonyms: Pifithrin hydrobromide;PFTα hydrobromide;Pifithrin-α

Pifithrin-α hydrobromide is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes.

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生物活性

实验方案

技术信息

生物活性

描述P53 is known as a transcription factor to control apoptotic cell death through regulating a series of target genes in nucleus^[3]. Pifithrin-α hydrobromide is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis^[4]. Pifithrin-α also acts as an aryl hydrocarbon receptor (AhR) agonist and. Pifithrin-α is a potent AhR agonist as determined by its ability to bind the AhR, induce formation of its DNA binding complex, activate reporter activity, and up-regulate the classic AhR target gene CYP1A1^[5]. When the experiment is performed with Pifthirin-α (PFT-α) hydrobromide, a pharmacological p53 inhibitor, the percentage of annexin V-positive Foxe3-/- SMCs decreases to WT levels. Pifithrin-α (2.2 mg/kg, i.p.) significantly reduces the incidence of aortic rupture and intramural hematomas in Foxe3-/- mice that underwent transverse aortic constriction (TAC) (50% to 17%, P<0.05). After Pifthirin-α treatment, the mean diameter of the ascending aorta and the percentage of TUNEL-positive cells in the aortic media are also normalized to WT levels in surviving Foxe3-/- animals^[6].
细胞研究
Cell Data
Cell Lines Concentration Assay Type Time Activity Description Data Sources
mouse E15.5 cortical neurones - Function assay - Inhibition of etoposide-induced death of mouse E15.5 cortical neurones 16759106

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
mouse E15.5 cortical neurones	-	Function assay	-	Inhibition of etoposide-induced death of mouse E15.5 cortical neurones	16759106

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7225 mL
- 13.6127 mL
- 27.2254 mL
- 5 mM
- 0.5445 mL
- 2.7225 mL
- 5.4451 mL
- 10 mM
- 0.2723 mL
- 1.3613 mL
- 2.7225 mL

技术信息

CAS号

63208-82-2

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H19BrN2OS

运输

蓝冰

分子量

367.30

别名

Pifithrin hydrobromide;PFTα hydrobromide;Pifithrin-α;PFT-α;Pifithrin-alpha;PFT-alpha

溶解度

DMSO	200.0 mg/mL (544.5 mM)
Water	insoluble

动物实验配方

IP	2% DMSO+water	2 mg/mL	clear
PO	0.5% CMC-Na	30 mg/mL	suspension

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