CAS No.: 511296-88-1
Pifithrin-β HBr Catalog No. CSN16420
Synonyms: PFT β hydrobromide;Cyclic Pifithrin-α hydrobromide;Cyclic PFT-α Hydrobromide
Pifithrin-β hydrobromide is a potent p53 inhibitor with IC50 of 23 μM in an antiproliferative assay in the human ovarian carcinoma cell line, IGROV-1.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
靶点 p53
IC50:23μM- 描述
- 参考文献
- [1] Da Pozzo E, La Pietra V, et al. p53 functional inhibitors behaving like pifithrin-β counteract the Alzheimer peptide non-β-amyloid component effects in human SH-SY5Y cells. ACS Chem Neurosci. 2014 May 21;5(5):390-9.
- [2] Christodoulou MS, Colombo F, et al. Synthesis and biological evaluation of imidazolo[2,1-b] benzothiazole derivatives, as potential p53 inhibitors. Bioorg Med Chem. 2011 Mar 1;19(5):1649-57.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 511296-88-1 | 储存条件 |
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| 分子式 | C16H17BrN2S | 运输 | 蓝冰 | |||||||
| 分子量 | 349.29 | 别名 | PFT β hydrobromide;Cyclic Pifithrin-α hydrobromide;Cyclic PFT-α Hydrobromide;Cyclic Pifithrin-α (hydrobromide);Cyclic PFT-α;PFT-β;Pifithrin-β;Pifithrin-beta;QB102;Cyclic-Pifithrin-α | |||||||
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动物实验配方 |
