|(2R,2'R,3S,3'S,4S,4'S,5R,5'R,6S,6'S)-6,6'-((((1S,3aR,4S,6aR)-六氢呋喃并[3,4- c]呋喃-1,4-二基)双(2-甲氧基-4,1-亚苯基))双(氧基)双(2-(羟甲基)四氢-2H-吡喃-3,4,5-三醇)|CsnPharm

CAS No.: 63902-38-5

Pinoresinol Diglucoside/松脂醇二葡萄糖苷 Catalog No. CSN18371

Synonyms: (+)-Pinoresinol di-O-β-D-glucopyranoside;松脂醇二葡萄糖苷

Pinoresinol diglucoside is one of the major lignans with various pharmacological activities which could be isolated from Duzhong and other plant species.

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技术信息

生物活性

描述Pinoresinol diglucoside (PDG) is one of the major lignans with various pharmacological activities which could be isolated from Duzhong and other plant species. PDG (5 mg/kg and 10 mg/kg) exerts anti-inflammatory and antioxidation effects via regulating the NF-κB pathway and Nrf2/HO-1 pathway, thereby reducing the I/R(ischemia/reperfusion)-induced brain injury of mice^[3]. PDG (5 and 10 mg/kg, i.g.) can attenuate neuroinflammation, neuronal apoptosis and oxidative stress through the TLR4/NF-κB and Nrf2/HO-1 pathways, and ameliorate memory dysfunction induced by Aβ1-42 in mice^[4]. PDG (2.5 mg/kg, 5 mg/kg, 7.5 mg/kg per day) treatment prevented cardiac histomorphology damages, decreased upregulations of hypertrophic biomarkers, and prevented fibrosis and inflammation after pressure overload resulting from AAC(abdominal aortic constriction)-surgery. Consistently, PDG remarkably inhibited the changes of cardiomyocyte hypertrophic biomarkers and inflammatory responses in cellular models of CM. PDG administration inhibited the activation of AKT/mTOR/NF-kB signaling pathway both in vivo and in vitro^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01619020	Healthy	Not Applicable	Completed	-	United States, Washington ... more >> FHCRC Seattle, Washington, United States, 98109 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.4648 mL
- 7.3242 mL
- 14.6484 mL
- 5 mM
- 0.2930 mL
- 1.4648 mL
- 2.9297 mL
- 10 mM
- 0.1465 mL
- 0.7324 mL
- 1.4648 mL

技术信息

CAS号	63902-38-5	储存条件	粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C32H42O16	运输	蓝冰
分子量	682.67	别名	(+)-Pinoresinol di-O-β-D-glucopyranoside;松脂醇二葡萄糖苷

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Pinoresinol Diglucoside/松脂醇二葡萄糖苷 Catalog No. CSN18371

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