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CAS No.: 153168-05-9

Pleconaril Catalog No. CSN11741

Synonyms: VP 63843;Win 63843;SR-263843

Pleconaril is a capsid inhibitor used previously to treat enterovirus infections. Pleconaril is effective in inhibiting replication with an IC50 of 50 nM.

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生物活性

描述Pleconaril is a capsid inhibitor used previously to treat enterovirus infections^[3]. Pleconaril binds to a hydrophobic pocket in the viral capsid inducing conformational changes, which lead to altered receptor binding and viral uncoating. Pleconaril is orally bioavailable and achieves serum concentrations in excess of those required to inhibit 90% of clinical rhino- and enteroviral isolates in vitro. It possesses the additional advantage of achieving several fold higher concentrations within the central nervous system and nasal secretions than in serum, a characteristic that is highly desirable for an antiviral targeted towards viruses known to cause central nervous system and upper respiratory tract infections. And pleconaril has demonstrated efficacy in the treatment of severe life-threatening enteroviral infections of the newborn and in immunosuppressed individuals^[4]. Moreover, pleconaril dramatically reduced virus levels in target tissues of coxsackievirus serotype B3 strain M-infected animals^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00031512	Enteroviral Sepsis	Phase 2	Completed	-	-
NCT00394914	Asthma Common... more >> Cold Picornavirus Infection Rhinovirus Collapse <<	Phase 2	Completed	-	-
NCT00394914	-	-	Completed	-	-

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.6223 mL
- 13.1113 mL
- 26.2227 mL
- 5 mM
- 0.5245 mL
- 2.6223 mL
- 5.2445 mL
- 10 mM
- 0.2622 mL
- 1.3111 mL
- 2.6223 mL

技术信息

CAS号

153168-05-9

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H18F3N3O3

运输

蓝冰

分子量

381.35

别名

VP 63843;Win 63843;SR-263843;SR-63843;Picovir

溶解度

DMSO	76.0 mg/mL (199.3 mM)
Water	Insoluble
Ethanol	75.0 mg/mL (196.7 mM)

动物实验配方

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