|Sirt2-PROTAC-1|CsnPharm

CAS No.: 2098487-75-1

PROTAC Sirt2 Degrader-1 Catalog No. CSN22311

Synonyms: Sirt2-PROTAC-1

PROTAC Sirt2 Degrader-12 is a PROTAC selectively targeting on Sirt2, consist an isotype-selective Sirt2 inhibitor SirReal as a warhead linked to cereblon ligand thalidomide.

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400-920-2911

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400-920-2911

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技术信息

生物活性

描述PROTAC Sirt2 Degrader-12 is a PROTAC selectively targeting on Sirt2, consist an isotype-selective Sirt2 inhibitor SirReal as a warhead linked to cereblon ligand thalidomide. PROTAC Sirt2 Degrader-12 led a selective and dose-dependent degradation of Sirt2 at concentration ranging in 0.2-5μM, as well as a time-dependent depletion of Sirt2 at concentration of 10μM post 0.5-2h with a max degradation observed at 2h in HeLa cells. Depletion of Sirt2 by PROTAC Sirt2 Degrader-1 at concentration of 10μM resulted in a more pronounced acetylation of the microtubule network with enhanced process elongation than enzymatic Sirt2 inhibition^[1].
参考文献

[1] Schiedel M, Herp D, et al. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem. 2018 Jan 25;61(2):482-491.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.1724 mL
- 5.8621 mL
- 11.7242 mL
- 5 mM
- 0.2345 mL
- 1.1724 mL
- 2.3448 mL
- 10 mM
- 0.1172 mL
- 0.5862 mL
- 1.1724 mL

技术信息

CAS号	2098487-75-1	储存条件	粉末液体 -20°C:3-6 月 -80°C:12月
分子式	C40H40N10O8S2	运输	蓝冰
分子量	852.94	别名	Sirt2-PROTAC-1

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