CAS No.: 2262488-39-9
S2157 Catalog No. CSN26667
S2157, a N-alkylated tranylcypromine (TCP) derivative, is a potent lysine-specific demethylase 1 (LSD1) inhibitor. S2157 increases H3K9 methylation and reciprocal H3K27 deacetylation at super-enhancer regions. S2157 induces apoptosis in TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells by repressing transcription of the NOTCH3 and TAL1 genes. S2157 efficiently pass through the blood-brain barrier and can almost completely eradicate CNS leukemia in mice transplanted with T-ALL cells[1].
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技术信息
| CAS号 | 2262488-39-9 | 储存条件 |
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| 分子式 | C23H28ClF2N3O2 | 运输 | 蓝冰 | |
| 分子量 | 451.94 | 别名 |
