CAS No.: 2050906-89-1
SAHM1/SAHM1游离态 Catalog No. CSN27258
SAHM1 is a stabilized hydrocarbon-stapled alpha helical peptide targeting Notch pathway. It mimics a dominant negative form of MAML, inhibits canonical Notch transcription complex formation.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 参考文献
- [1] Ashley JW, Ahn J, Hankenson KD. Notch signaling promotes osteoclast maturation and resorptive activity. J Cell Biochem. 2015;116(11):2598-2609. doi:10.1002/jcb.25205
- [2] Bagheri L, Pellati A, Rizzo P, et al. Notch pathway is active during osteogenic differentiation of human bone marrow mesenchymal stem cells induced by pulsed electromagnetic fields. J Tissue Eng Regen Med. 2018;12(2):304-315. doi:10.1002/term.2455
- [3] KleinJan A, Tindemans I, Montgomery JE, et al. The Notch pathway inhibitor stapled α-helical peptide derived from mastermind-like 1 (SAHM1) abrogates the hallmarks of allergic asthma. J Allergy Clin Immunol. 2018;142(1):76-85.e8. doi:10.1016/j.jaci.2017.08.042
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 2050906-89-1 | 储存条件 |
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| 分子式 | C94H162N36O23S | 运输 | 蓝冰 | |
| 分子量 | 2196.58 | 别名 |
