|(3S,3aS,5aS,9bS)-3,5a,9-三甲基-3a,4,5,5a-四氢萘并[1,2-b]呋喃-2,8(3H,9bH)-二酮|CsnPharm

CAS No.: 481-06-1

Santonin/山道年 Catalog No. CSN21900

Synonyms: Alpha-Santonin;NSC-4900;山道年

(-)-α-Santonin is a naturally occurring sesquiterpene lactone, it's a potent antiparasitic agent.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述α-Santonin, a sesquiterpene lactone isolated from Artemisia Santonica, possesses diverse bioactivities including antioxidant, anti-inflammation, immunosuppressive, anti-roundworm, anti-malaria, etc^[2]. Ten novel α-santonin derivatives have been synthesized as cytotoxic agents. The compounds 2-4, possessing the α-methylene-γ-lactone group showed IC50 values between 5.70 and 16.40 μM. Mixture of isomers 5 and 6, with the α-methylene-γ-lactone and endoperoxide functionalities, displayed the greatest activity, with IC50 values between 1.45 and 4.35 μM^[3]. Derivative 5h (α-santonin-derived compounds) was more potent than the positive control 5-fluorouracil (5-Fu) on HepG-2, QGY-7703 and SMMC-7721 with IC50 values of 7.51, 3.06 and 4.08 μM, respectively. Moreover, the derivatives induced hepatoma cells apoptosis by facilitating apoptosis-related proteins expressions^[4].
参考文献

[2] Wang J, Su S, Zhang S, et al. Structure-activity relationship and synthetic methodologies of α-santonin derivatives with diverse bioactivities: A mini-review. Eur J Med Chem. 2019;175:215-233
[3] Arantes FF, Barbosa LC, Maltha CR, et al. Synthesis of novel α-santonin derivatives as potential cytotoxic agents. Eur J Med Chem. 2010;45(12):6045-6051
[4] Chen H, Yang X, Yu Z, et al. Synthesis and biological evaluation of α-santonin derivatives as anti-hepatoma agents. Eur J Med Chem. 2018;149:90-97

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.0601 mL
- 20.3004 mL
- 40.6009 mL
- 5 mM
- 0.8120 mL
- 4.0601 mL
- 8.1202 mL
- 10 mM
- 0.4060 mL
- 2.0300 mL
- 4.0601 mL

技术信息

CAS号

481-06-1

储存条件

粉末: Keep in dark place,Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H18O3

运输

蓝冰

分子量

246.30

别名

Alpha-Santonin;NSC-4900;山道年;(-)-α-桑东宁

溶解度

DMSO	61.0 mg/mL (247.7 mM)
Water	insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Santonin/山道年 Catalog No. CSN21900

靶点选择性

请登录您的专属账户

确认信息