400-920-2911 sales@csnpharm.cn
您的位置 : 首页 / MAPK/ERK Pathway / p38 MAPK / SB 203580
CAS No.: 152121-47-6
Synonyms: RWJ 64809;PB-203580;AdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimod
SB-203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM.
生物活性
靶点 | p38 MAPK IC50:0.3-0.5μM |
实验方案
技术信息
CAS号 | 152121-47-6 | 储存条件 |
|
|||||||||||||
分子式 | C21H16FN3OS | 运输 | 蓝冰 | |||||||||||||
分子量 | 377.43 | 别名 | RWJ 64809;PB-203580;AdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimodAdezmapimod;SB-203850;SB 203580 | |||||||||||||
溶解度 |
|
动物实验配方 |
|
Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
---|
HCA2 | 2.5 μM | Function Assay | - | Inhibits p38 mediated MK2 activation | 17964780 |
Hela | - | Function Assay | - | Inhibits Tat-induced HIV1 LTR transactivation in human HeLa cells with IC50 of 0.1 μM | 18926711 |
hESCs | 5 μM | Growth Inhibition Assay | - | Induces cardiomyogenic activity assessed as cell growth | 23602399 |
IEC-18 | 10 μM | Function Assay | - | Inhibits LPS-induced p38 MAPK phosphorylation | 23758110 |
PBMC | - | Function Assay | 15 min | Inhibits the release of interleukin-1-beta with IC50 of 0.037 μM | 12361396 |
PC12 | 10 μM | Kinase Assay | 15 min | Inhibits p38 MAP kinase with IC50 of 0.6 μM | 7750577 |
PC12 | 10 μM | Function Assay | - | Activates Nrf2/ARE in rat PC12 cells assessed as HO-1 protein induction | 21345685 |
RAW 264.7 | 12.5 μM | Cytotoxic Assay | 12h | Blocks lethal toxin-mediated cytotoxicity | 17485504 |
RAW264.7 | 10 μM | Function Assay | - | Induces antiinflammatory activity by inhibiting IL-1β release | 23791078 |
RAW264.7 | 10 μM | Function Assay | - | Induces antiinflammatory activity by inhibiting iNOS release | 23791078 |
RAW264.7 | 10 μM | Function Assay | - | Induces antiinflammatory activity by inhibiting NO release | 23791078 |
RAW264.7 | 10 μM | Function Assay | - | Inhibits LPS-induced p38 MAPK phosphorylation | 24016057 |
SW1353 | - | Function Assay | 1 h | Inhibits IL-6 production with IC50 of 0.05 μM | 11140741 |
THP-1 | - | Function Assay | - | Inhibits LPS-induced TNFalpha production with IC50 of 0.16 μM | 18325768 |
U937 | - | Function Assay | - | Inhibits JAK-mediated interferon-gamma/anisomycin-induced Stat1 phosphorylation | 18157122 |
U937 | - | Function Assay | - | Inhibits JAK-mediated interferon-gamma/anisomycin-induced p38 phosphorylation | 18157122 |
靶点 | Description | IC50 |
---|---|---|
p38 MAPK | IC50:0.3-0.5μM |
联系我们
官方电话:400-920-2911
二维码
微信公众号 CSN官网