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CAS No.: 529-53-3

Scutellarein/野黄芩素 Catalog No. CSN12258

Synonyms: 6-Hydroxyapigenin;4',5,6,7-Tetrahydroxyflavone;野黄芩素

Scutellarin is cytotoxic to cancer cells and could induce DNA damage, metabolic suppression and mitochondrial reactive oxygen species. It has has antioxidant, anti-inflammatory, and antiproliferative biological activities that can be can be found in scutellaria lateriflora.

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技术信息

生物活性

描述Scutellarein is a flavonoid monomer found in traditional Chinese medicine such as Scutellaria barbata. Scutellarein treatment showed potent cytotoxicity on MM (multiple myeloma) cells but not on viable CBL(circulating B lymphocytes), and intravenous injection of scutellarein significantly reduced MM xenograft tumor burden in nude mice. Scutellarein treatment in MM cells activated the mitochondrial-mediated intrinsic apoptosis pathway by increasing the production of mitochondrial superoxide, which was reduced to ROS by NADPH, but this effect was weakened in healthy CBL. Co-treatment with scutellarein synergized with bortezomib in inducing apoptosis in MM cells in vitro and in reducing tumor volume in MM xenografted nude mice^[3]. Scutellarein can induce apoptosis of HCT116 cells. Scutellarein can increase the production of intracellular ROS and lead to the collapse of mitochondrial membrane potential. Meanwhile, the activity of caspase-3 in HCT116 cells was elevated by scutellarein. Moreover, down-regulated Bcl-2 and up-regulated Bax were observed. Additionaly, scutellarein resulted in cytochrome c release from mitochondria^[4]. Scutellarein has antiproliferative index against multiple cancer cell lines and diminished the oxidative stress and tumor development of murine ascitic lymphoma & inflammatory hepatocellular carcinoma^[5]. Scutellarein possesses important novel anti-obesity effects accompanying lipid lowering and anti-inflammation-based liver protective effects. The antagonistic effect of Scutellarein on hyperlipidemia was a result of the repression of the lipid synthesis pathway, de novo pathway, HMGCR, promoting fatty acid oxidation (PPARα, CPT-1a) and increased cholesterol output (PPARγ-LXRα-ABCA1)^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.4936 mL
- 17.4681 mL
- 34.9362 mL
- 5 mM
- 0.6987 mL
- 3.4936 mL
- 6.9872 mL
- 10 mM
- 0.3494 mL
- 1.7468 mL
- 3.4936 mL

技术信息

CAS号

529-53-3

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H10O6

运输

蓝冰

分子量

286.24

别名

6-Hydroxyapigenin;4',5,6,7-Tetrahydroxyflavone;野黄芩素;高黄芩素

溶解度

DMSO	57.0 mg/mL (199.1 mM)

动物实验配方

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