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CAS No.: 302-95-4

Sodium Deoxycholate/脱氧胆酸钠 Catalog No. CSN25392

Synonyms: Sodium deoxycholate;脱氧胆酸钠

Deoxycholic acid sodium salt is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.

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技术信息

生物活性

描述Deoxycholic acid sodium salt is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity^[3]. Deoxycholic acid (DCA) and chenoDeoxycholic acid (CDCA), as the common ingredients of duodenal reflux, act synergistically in many physiological and pathological processes. To simulate chronic local recurrent disease in vitro, the gastric cancer cell line MGC803 is exposed to acidified medium (pH 5.5) containing 100 μM Deoxycholic acid and CDCA. An untreated log-growth MGC803 cell line is generated to be used as a control in normal pH media. After daily 10 min exposure to the acidified bile acids for 60 weeks, MGC803-resistant cells are able to survive and proliferate after 120 min exposure^[2].
参考文献

[1] Somm E, et al. β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue. JCI Insight. 2017 Apr 20;2(8). pii: 91809.
[2] Wang X, Sun L, Wang X, et al. Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in mice dependent on c-Myc expression. Cancer Med. 2017;6(4):788‐797
[3] Somm E, Henry H, Bruce SJ, et al. β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue. JCI Insight. 2017;2(8):e91809. Published 2017 Apr 20

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4122 mL
- 12.0612 mL
- 24.1223 mL
- 5 mM
- 0.4824 mL
- 2.4122 mL
- 4.8245 mL
- 10 mM
- 0.2412 mL
- 1.2061 mL
- 2.4122 mL

技术信息

CAS号

302-95-4

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H39NaO4

运输

蓝冰

分子量

414.55

别名

Sodium deoxycholate;脱氧胆酸钠

溶解度

DMSO	80.0 mg/mL (193.0 mM)
Ethanol	80.0 mg/mL (193.0 mM)

动物实验配方

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