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CAS No.: 3106-85-2

Spaglumic Acid/异冬谷酸 Catalog No. CSN23124

Synonyms: N-Acetylaspartylglutamic acid;α-NAAG;NAAG

Spaglumic Acid is a neuropeptide found in millimolar concentrations in brain.

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技术信息

生物活性

描述Spaglumic Acid (N-Acetylaspartylglutamic acid, NAAG) is a neuropeptide found in millimolar concentrations in brain that is localized to subpopulations of glutamatergic, cholinergic, GABAergic, and noradrenergic neuronal systems. NAAG is released upon depolarization by a Ca(2+)-dependent process and is an agonist at mGluR3 receptors and an antagonist at NMDA receptors^[1]. EB (Evans blue) ocular extravasation was significantly lower in the eyes treated by spaglumic acid and emedastine. Spaglumic acid and emedastine seem to be the most useful drugs to reduce EB extravasation and allergic signs in an animal model of early phase allergic conjunctivitis^[2]. The organ function decrease may be attributed by transcription alteration, inflammation response, and metabolic alteration in liver after BD. Spaglumic acid and halcinonide may be potential drugs for preventing organ damage during the BD (brain death) process^[3].
参考文献

[1] Coyle JT. The nagging question of the function of N-acetylaspartylglutamate. Neurobiol Dis. 1997;4(3-4):231-8
[2] Sanchis-Merino ME, Montero JA, Ruiz-Moreno JM, Rodriguez AE, Pastor S. Comparative efficacy of topical antihistamines in an animal model of early phase allergic conjunctivitis. Exp Eye Res. 2008 May;86(5):791-7
[3] Liu Q, Ye Q. Computationally Prediction of Candidate Agents for Preventing Organ Dysfunction After Brain Death. Ann Transplant. 2016 May 12;21:301-10

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.2867 mL
- 16.4337 mL
- 32.8674 mL
- 5 mM
- 0.6573 mL
- 3.2867 mL
- 6.5735 mL
- 10 mM
- 0.3287 mL
- 1.6434 mL
- 3.2867 mL

技术信息

CAS号

3106-85-2

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C11H16N2O8

运输

蓝冰

分子量

304.25

别名

N-Acetylaspartylglutamic acid;α-NAAG;NAAG

溶解度

Water

250.0 mg/mL (821.7 mM) warming

动物实验配方

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