|3,4,5-三甲氧基-N-(2-(3-(哌嗪-1-基甲基)咪唑并[2,1-b]噻唑-6-基)苯基)苯甲酰胺|CsnPharm

CAS No.: 925432-73-1

SRT 1460 Catalog No. CSN25631

Synonyms: ANW-57653

SRT1460 is a SIRT1 activator with EC50 value of 2.9μM in an in vitro fluorescence polarization assay.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Sirtuin-1 (SIRT1), a NAD⁺-dependent deacetylase, is a principal modulator of pathways downstream of calorie restriction that produce beneficial effects on glucose homeostasis and insulin sensitivity. SRT1460 is a potent SIRT1 activator with an EC_1.5 (concentration required to increase enzyme activity by 50%) value of 2.9 μM, shows good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 μM), and is more potent than Resveratrol and the closest sirtuin homologues^[1]. Treatment with different concentrations of SRT1460 inhibited cell viability in a dose-dependent manner, with all pancreatic cancer cells being more sensitive than the control HPDE cell. SRT1460 was also shown to inhibited cell growth by the Trypan blue exclusion and in the anchorage-independent cell growth assays in Patu8988t^[2].
作用机制SRT1460 binds to the SIRT1 enzyme-peptide substrate complex at an allosteric site amino-terminal to the catalytic domain^[1].
参考文献

[1] Milne JC, Lambert PD, Schenk S, et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007;450(7170):712-716
[2] Chini CC, Espindola-Netto JM, Mondal G, et al. SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent Pathway. Clin Cancer Res. 2016;22(10):2496-2507

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.9700 mL
- 9.8502 mL
- 19.7004 mL
- 5 mM
- 0.3940 mL
- 1.9700 mL
- 3.9401 mL
- 10 mM
- 0.1970 mL
- 0.9850 mL
- 1.9700 mL

技术信息

CAS号

925432-73-1

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C26H29N5O4S

运输

蓝冰

分子量

507.60

别名

ANW-57653

溶解度

DMSO	20.0 mg/mL (39.4 mM)
Water	Insoluble
Ethanol	1.0 mg/mL (2.0 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

SRT 1460 Catalog No. CSN25631

靶点选择性

请登录您的专属账户

确认信息