|4-(1,1-二氧代-1,2-硫代吗啉-2-基)苯磺酰胺|CsnPharm

CAS No.: 61-56-3

Synonyms: Sulthiame;ospolot;RP-10284

Sultiame is an inhibitor of carbonic anhydrase that used to treat epilepsy.

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描述Sultiame is a carbonic anhydrase (CA) inhibitor, widely used as an antiepileptic drug^[2]. CA inhibitors (CAIs) such as acetazolamide, methazolamide, topiramate, zonisamide, and sulthiame (Sultiame) can reduce seizures through perturbation of the CO(2) equilibrium and/or the inhibition of ion channels^[3]. Drugs inhibiting metabolism include antibiotic macrolides, chloramphenicol, isoniazide, some sulphonamides, propoxyphene, cimetidine, valproic acid and sulthiame. Anti-epileptic drugs can induce hepatic microsomal enzymes and, therefore, may increase metabolism of corticosteroids, oral contraceptives, oral anticoagulants, cardiovascular agents, antibiotics, chemotherapeutic agents, psychotropic drugs and non-opiate analgesics, thereby reducing their efficacy^[4]. The high tolerability, efficacy, convenience of use and low cost suggest that sulthiame should become a first line drug in the benign partial epilepsies of childhood and juvenile myoclonic epilepsy. It also has a role as add-on treatment in other partial and myoclonic epilepsies^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03400189	Epilepsy	Phase 1	Active, not recruiting	August 30, 2018	Switzerland ... more >> Division of Clinical Pharmacology Lausanne, Vaud, Switzerland, 1011 Collapse <<
NCT00471744	Epilepsy, Rolandic	Phase 3	Terminated(low patient number ... more >>after 2 years recruiting) Collapse <<	-	Germany ... more >> Dr. von Haunersches Kinderspital München, Germany, 81371 Collapse <<

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