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CAS No.: 293754-55-9
Synonyms: T-1317;TO-91317;TO 901317
T0901317 is a selective agonist for LXR and FXR with EC50 of 50 nM and 5 μM, respectively.
生物活性
实验方案
技术信息
CAS号 | 293754-55-9 | 储存条件 |
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分子式 | C17H12F9NO3S | 运输 | 蓝冰 | |||||||||||||
分子量 | 481.33 | 别名 | T-1317;TO-91317;TO 901317;TO-091317 | |||||||||||||
溶解度 |
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动物实验配方 |
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Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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CHO cells | - | Function assay | - | Agonist activity at human LXR beta receptor expressed in CHO cells by reporter assay, EC50=16 nM | 19853462 |
COS7 cells | - | Function assay | 16 h | Agonist activity at human LXRbeta receptor transfected in COS7 cells after 16 hrs by reporter transactivation assay, EC50=11 nM | 17587573 |
CV1 cells | - | Function assay | - | Transactivation of LXRbeta (unknown origin) expressed in CV1 cells by luciferase reporter gene assay, EC50=0.14 μM | 25435151 |
HEK293 cells | - | Function assay | - | Agonist activity at human LXRbeta in HEK293 cells assessed as Gal4 transactivation, EC50=19 nM | 20350005 |
HepG2 cells | - | Function assay | - | Effect on SREBP1c gene expression in human HepG2 cells, EC50=0.061 μM | 18973288 |
HuH7 cells | - | Function assay | - | Upregulation of SREB1c mRNA level in human HuH7 cells, EC50=0.036 μM | 20382019 |
human H4 cells | - | Function assay | - | Effect on gamma-secretase activity in human H4 cells expressing APP695 assessed as increase in Amyloid beta-42 formation LPECL assay, EC50=3.6 μM | 17723298 |
mouse J774 cells | - | Function assay | - | Agonist activity at LXRbeta in mouse J774 cells assessed as upregulation of ABCA1 mRNA expression, EC50=0.027 μM | 19853462 |
mouse J774A1 cells | - | Function assay | 18 h | Induction of ABCA1 mRNA expression in mouse J774A1 cells after 18 hrs by RT-PCR, EC50=0,034 μM | 19394832 |
SH-SY5Y cells | - | Function assay | 24 h | Agonist activity at human LXRbeta expressed in human SH-SY5Y cells co-transfected with Gal4-LBD after 24 hrs by luciferase reporter gene assay, EC50=0.075 μM | 19264481 |
THP1 cells | - | Function assay | - | Stimulation of [3H]cholesterol efflux in human THP1 foam cells loaded with ac-LDL, EC50=3 nM | 19962892 |
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