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CAS No.: 1258861-20-9
Synonyms: LY2940680
LY2940680 can bind to the Smo receptor and inhibit hedgehog signaling.
生物活性
动物研究 | |
剂量 | Mice: 20 mg/kg[3] (p.o.) |
给药途径 | p.o. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT02530437 | Gastroesophageal Junction Aden... more >>ocarcinoma Stage IB Esophageal Adenocarcinoma AJCC v7 Stage II Esophageal Adenocarcinoma AJCC v7 Stage IIA Esophageal Adenocarcinoma AJCC v7 Stage IIB Esophageal Adenocarcinoma AJCC v7 Stage IIIA Esophageal Adenocarcinoma AJCC v7 Stage IIIB Esophageal Adenocarcinoma AJCC v7 Collapse << | Phase 1 Phase 2 | Active, not recruiting | March 31, 2023 | United States, Texas ... more >> M D Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
NCT02784795 | Solid Tumor B... more >>reast Cancer Colon Cancer Cholangiocarcinoma Soft Tissue Sarcoma Collapse << | Phase 1 | Active, not recruiting | January 31, 2019 | United States, Florida ... more >> Sylvester Comprehensive Cancer Center Miami, Florida, United States, 33136 United States, Michigan Karmanos Cancer Institute Detroit, Michigan, United States, 48201 United States, New York Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 United States, Texas University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Denmark Rigshospitalet Copenhagen, København Ø, Denmark, 2100 France Institut Bergonie Bordeaux, France, 33076 Centre Leon Berard Lyon Cedex 08, France, 69373 Gustave Roussy Villejuif Cedex, France, 94805 Spain Hospital Universitari Vall d'Hebron Barcelona, Spain, 08035 Fundacion Jimenez Diaz Madrid, Spain, 28040 Hospital Madrid Norte Sanchinarro Madrid, Spain, 28050 Collapse << |
NCT01681186 | Healthy Volunteers | Phase 1 | Completed | - | United States, Texas ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Dallas, Texas, United States Collapse << |
实验方案
技术信息
CAS号 | 1258861-20-9 | 储存条件 |
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分子式 | C26H24F4N6O | 运输 | 蓝冰 | |||||||||||||
分子量 | 512.50 | 别名 | LY2940680 | |||||||||||||
溶解度 |
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动物实验配方 |
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NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT02530437 | Gastroesophageal Junction Aden... more >>ocarcinoma Stage IB Esophageal Adenocarcinoma AJCC v7 Stage II Esophageal Adenocarcinoma AJCC v7 Stage IIA Esophageal Adenocarcinoma AJCC v7 Stage IIB Esophageal Adenocarcinoma AJCC v7 Stage IIIA Esophageal Adenocarcinoma AJCC v7 Stage IIIB Esophageal Adenocarcinoma AJCC v7 Collapse << | Phase 1 Phase 2 | Active, not recruiting | March 31, 2023 | United States, Texas ... more >> M D Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
NCT02784795 | Solid Tumor B... more >>reast Cancer Colon Cancer Cholangiocarcinoma Soft Tissue Sarcoma Collapse << | Phase 1 | Active, not recruiting | January 31, 2019 | United States, Florida ... more >> Sylvester Comprehensive Cancer Center Miami, Florida, United States, 33136 United States, Michigan Karmanos Cancer Institute Detroit, Michigan, United States, 48201 United States, New York Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 United States, Texas University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Denmark Rigshospitalet Copenhagen, København Ø, Denmark, 2100 France Institut Bergonie Bordeaux, France, 33076 Centre Leon Berard Lyon Cedex 08, France, 69373 Gustave Roussy Villejuif Cedex, France, 94805 Spain Hospital Universitari Vall d'Hebron Barcelona, Spain, 08035 Fundacion Jimenez Diaz Madrid, Spain, 28040 Hospital Madrid Norte Sanchinarro Madrid, Spain, 28050 Collapse << |
NCT01681186 | Healthy Volunteers | Phase 1 | Completed | - | United States, Texas ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Dallas, Texas, United States Collapse << |
NCT01746745 | Healthy Volunteers | Phase 1 | Completed | - | United States, Wisconsin ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Madison, Wisconsin, United States, 53704 Collapse << |
NCT01226485 | Advanced Cancer | Phase 1 | Completed | - | United States, Arizona ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Scottsdale, Arizona, United States, 85260 United States, California For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Redwood City, California, United States, 94063 United States, Colorado For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Aurora, Colorado, United States, 80045 United States, Florida For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Fort Myers, Florida, United States, 33908 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Tampa, Florida, United States, 33612 United States, Nevada For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Las Vegas, Nevada, United States, 89169 United States, New York For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. New York, New York, United States, 10065 United States, Oklahoma For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Oklahoma City, Oklahoma, United States, 73104 United States, Tennessee For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Nashville, Tennessee, United States, 37203 United States, Texas For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Fort Worth, Texas, United States, 76177 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Houston, Texas, United States, 77030 For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Tyler, Texas, United States, 75702 Collapse << |
NCT01722292 | Small Cell Lung Carcinoma | Phase 1 Phase 2 | Terminated(Change in clinical ... more >>strategy.) Collapse << | - | United States, Arkansas ... more >> Highlands Oncology Group Fayetteville, Arkansas, United States, 72703 United States, Georgia Northeast Georgia Cancer Care, LLC Athens, Georgia, United States, 30607 United States, Nevada Comprehensive Cancer Centers of Nevada Las Vegas, Nevada, United States, 89169 United States, New York New York Oncology Hematology Associate Albany, New York, United States, 12206 Mount Sinai Medical Center New York, New York, United States, 10029 United States, South Carolina Clinical Research Unit (ITOR) Greenville Hospital System Greenville, South Carolina, United States, 29605 United States, Tennessee Accelerated Comm. Oncology Research Network (ACORN) Memphis, Tennessee, United States, 38119 The West Clinic Memphis, Tennessee, United States, 38120 United States, Texas US Oncology The Woodlands, Texas, United States, 77380 Tyler Cancer Center Tyler, Texas, United States, 75702 United States, Washington Northwest Cancer Specialists PC Vancouver, Washington, United States, 98684 Yakima Valley Memorial Hospital Yakima, Washington, United States, 98902 United Kingdom For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. London, United Kingdom, SE1 9RT For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Manchester, United Kingdom, M20 4BX Collapse << |
NCT01697514 | Medulloblastoma, Childhood ... more >> Rhabdomyosarcoma Collapse << | Phase 1 | Withdrawn(Trial stopped early ... more >>for poor accrual.) Collapse << | July 2016 | United States, California ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. San Diego, California, United States, 92123 United States, Colorado For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Aurora, Colorado, United States, 80045 United States, Ohio For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Cincinnati, Ohio, United States, 45229 United States, Oregon For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Portland, Oregon, United States, 97239 Collapse << |
NCT01919398 | Neoplasm Metastasis | Phase 1 | Active, not recruiting | June 2017 | Japan ... more >> For additional information regarding investigative sites for this trial, contact 1-858-255-5959 Mon - Fri from 9 AM to 5 PM Pacific Time (PST), or speak with your personal physician. Shizuoka, Japan, 411-8777 For additional information regarding investigative sites for this trial, contact 1-858-255-5959 Mon - Fri from 9 AM to 5 PM Pacific Time (PST), or speak with your personal physician. Tokyo, Japan, 104-0045 Collapse << |
靶点 | Description | IC50 |
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