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CAS No.: 1207456-01-6
Synonyms: BMN-673;LT-673;MDV-3800
BMN-673 is a PARP1/2 inhibitor with IC50 of 0.57 nM for PARP1.
生物活性
靶点 | PARP1 IC50:0.57nM |
动物研究 | |
剂量 | Nude Mice: o.1 mg/kg, 0.33 mg/kg[1] (p.o.) |
给药途径 | p.o. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT01042379 | Breast Neoplasms ... more >> Breast Cancer Breast Tumors Collapse << | Phase 2 | Recruiting | - | - |
NCT03077607 | Advanced Solid Tumors | Phase 1 | Completed | - | Hungary ... more >> PRA Magyarorszag Kft, Fazis I-es Klinikai Farmakologiai Vizsgalohely Budapest, Hungary, 1077 Moldova, Republic of ARENSIA Exploratory Medicine Phase I Unit, PMSI Institute of Oncology Chisinau, Moldova, Republic of, MD2025 Poland Szpital LUX MED Warsaw, Poland, 02-801 Russian Federation I.M. Sechenov First Moscow State Medical University Moscow, Russian Federation, 119435 I.M. Sechenov First Moscow State Medical University Moscow, Russian Federation, 119991 "BioEq" LLC Saint-Petersburg, Russian Federation, 197342 State budget healthcare institution of Yaroslavl region "Regional clinical oncology hospital" Yaroslavl, Russian Federation, 150054 Collapse << |
NCT03642132 | Ovarian Cancer | Phase 3 | Recruiting | May 18, 2026 | - |
实验方案
技术信息
CAS号 | 1207456-01-6 | 储存条件 |
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分子式 | C19H14F2N6O | 运输 | 蓝冰 | |||||||||||||
分子量 | 380.35 | 别名 | BMN-673;LT-673;MDV-3800;Talzenna;他拉唑帕利 | |||||||||||||
溶解度 |
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动物实验配方 |
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Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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BR5FVB1-Akt | 0.1-100 nM | Growth Inhibition Assay | 24/48/72 h | inhibits cell proliferation dose dependently | 26047697 |
BR5FVB1-Akt | 0.1-100 nM | Apoptosis Assay | 72 h | induces apoptosis | 26047697 |
BT-12 | - | Growth Inhibition Assay | - | IC50> 1,000 nM | 25263539 |
Capan-1 | - | Growth Inhibition Assay | - | IC50=16.0 ± 5.4 µM | 25864590 |
CCRF-CEM | - | Growth Inhibition Assay | - | IC50=697.3 nM | 25263539 |
CHLA-10 | - | Growth Inhibition Assay | - | IC50=67.8 nM | 25263539 |
CHLA-136 | - | Growth Inhibition Assay | - | IC50=14.2 nM | 25263539 |
CHLA-258 | - | Growth Inhibition Assay | - | IC50=4.6 nM | 25263539 |
CHLA-266 | - | Growth Inhibition Assay | - | IC50> 1,000 nM | 25263539 |
CHLA-9 | - | Growth Inhibition Assay | - | IC50=8.2 nM | 25263539 |
CHLA-90 | - | Growth Inhibition Assay | - | IC50> 1,000 nM | 25263539 |
COG-LL-317 | - | Growth Inhibition Assay | - | IC50=9.4 nM | 25263539 |
COR-L279 | - | Growth Inhibition Assay | - | IC50=15 nM | 24077350 |
DMS-79 | - | Growth Inhibition Assay | - | IC50=9.3 nM | 24077350 |
DT40 | - | Growth Inhibition Assay | - | IC50=4 nM | 24356813 |
DU145 | - | Growth Inhibition Assay | - | IC50=11 nM | 24356813 |
H1048 | - | Growth Inhibition Assay | - | IC50=2.2 nM | 24077350 |
H1092 | - | Growth Inhibition Assay | - | IC50=8.9 nM | 24077350 |
H1930 | - | Growth Inhibition Assay | - | IC50=4.1 nM | 24077350 |
H2081 | - | Growth Inhibition Assay | - | IC50=6.3 nM | 24077350 |
H209 | - | Growth Inhibition Assay | - | IC50=1.7 nM | 24077350 |
H2107 | - | Growth Inhibition Assay | - | IC50=7.3 nM | 24077350 |
H446 | - | Growth Inhibition Assay | - | IC50=13 nM | 24077350 |
H524 | - | Growth Inhibition Assay | - | IC50=3.1 nM | 24077350 |
H69 | - | Growth Inhibition Assay | - | IC50=5.2 nM | 24077350 |
Karpas-299 | - | Growth Inhibition Assay | - | IC50=75.7 nM | 25263539 |
Kasumi-1 | - | Growth Inhibition Assay | - | IC50=786.2 nM | 25263539 |
MIA PaCa-2 | - | Growth Inhibition Assay | - | IC50=58.23 ± 8.1 µM | 25864590 |
MOLT-4 | - | Growth Inhibition Assay | - | IC50=16.6 nM | 25263539 |
NALM-6 | - | Growth Inhibition Assay | - | IC50=49 nM | 25263539 |
NB-1643 | - | Growth Inhibition Assay | - | IC50=18.4 nM | 25263539 |
NB-EBc1 | - | Growth Inhibition Assay | - | IC50=25.8 nM | 25263539 |
Ramos-RA1 | - | Growth Inhibition Assay | - | IC50=68.3 nM | 25263539 |
RD | - | Growth Inhibition Assay | - | IC50=8.7 nM | 25263539 |
Rh18 | - | Growth Inhibition Assay | - | IC50=4.9 nM | 25263539 |
Rh30 | - | Growth Inhibition Assay | - | IC50=31.1 nM | 25263539 |
Rh41 | - | Growth Inhibition Assay | - | IC50=8.1 nM | 25263539 |
RS4;11 | - | Growth Inhibition Assay | - | IC50=52.6 nM | 25263539 |
SJ-GBM2 | - | Growth Inhibition Assay | - | IC50=16.2 nM | 25263539 |
TC-71 | - | Growth Inhibition Assay | - | IC50=3.7 nM | 25263539 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT01042379 | Breast Neoplasms ... more >> Breast Cancer Breast Tumors Collapse << | Phase 2 | Recruiting | - | - |
NCT03077607 | Advanced Solid Tumors | Phase 1 | Completed | - | Hungary ... more >> PRA Magyarorszag Kft, Fazis I-es Klinikai Farmakologiai Vizsgalohely Budapest, Hungary, 1077 Moldova, Republic of ARENSIA Exploratory Medicine Phase I Unit, PMSI Institute of Oncology Chisinau, Moldova, Republic of, MD2025 Poland Szpital LUX MED Warsaw, Poland, 02-801 Russian Federation I.M. Sechenov First Moscow State Medical University Moscow, Russian Federation, 119435 I.M. Sechenov First Moscow State Medical University Moscow, Russian Federation, 119991 "BioEq" LLC Saint-Petersburg, Russian Federation, 197342 State budget healthcare institution of Yaroslavl region "Regional clinical oncology hospital" Yaroslavl, Russian Federation, 150054 Collapse << |
NCT03642132 | Ovarian Cancer | Phase 3 | Recruiting | May 18, 2026 | - |
NCT03330405 | Avelumab in Combination With T... more >>alazoparib Will be Investigated in Patients With Locally Advanced (Primary or Recurrent) or Metastatic Solid Tumors Collapse << | Phase 2 | Recruiting | March 28, 2020 | - |
NCT02154490 | Recurrent Squamous Cell Lung C... more >>arcinoma Stage IV Squamous Cell Lung Carcinoma AJCC v7 Collapse << | Phase 2 Phase 3 | Recruiting | April 1, 2022 | - |
NCT03148795 | Prostate Cancer | Phase 2 | Recruiting | March 3, 2022 | - |
NCT03637491 | Pancreatic Cancer ... more >> Non-Small Cell Lung Cancer Cancer Collapse << | Phase 2 | Recruiting | November 7, 2022 | United States, Arkansas ... more >> Highlands Oncology Group Not yet recruiting Fayetteville, Arkansas, United States, 72703 Highlands Oncology Group Not yet recruiting Rogers, Arkansas, United States, 72758 United States, California California Cancer Associates for Research and Excellence, Inc (cCARE) Not yet recruiting Encinitas, California, United States, 92024 California Cancer Associates for Research and Excellence, Inc (cCARE) Not yet recruiting San Marcos, California, United States, 92069 United States, Colorado University of Colorado Denver CTO (CTRC) Recruiting Aurora, Colorado, United States, 80045 University of Colorado Hospital Recruiting Aurora, Colorado, United States, 80045 United States, Indiana Horizon Oncology Research, LLC Recruiting Lafayette, Indiana, United States, 47905 United States, Pennsylvania UPMC Hillman Cancer Center Investigational Drug Service Not yet recruiting Pittsburgh, Pennsylvania, United States, 15232 UPMC Hillman Cancer Center Not yet recruiting Pittsburgh, Pennsylvania, United States, 15232 United States, Texas The University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 United States, Utah University of Utah, Huntsman Cancer Hospital Recruiting Salt Lake City, Utah, United States, 84112 University of Utah, Huntsman Cancer Institute Recruiting Salt Lake City, Utah, United States, 84112 Collapse << |
NCT02921919 | Cancer | Phase 2 | Recruiting | September 30, 2020 | - |
NCT03395197 | mCRPC | Phase 3 | Recruiting | November 2024 | United States, Alaska ... more >> Alaska Urological Institute dba Alaska Clinical Research Center Not yet recruiting Anchorage, Alaska, United States, 99503 United States, Arizona Urological Associates of Southern Arizona, PC Recruiting Tucson, Arizona, United States, 85715 Urological Associates of Southern Arizona, P.C. Recruiting Tucson, Arizona, United States, 85741 United States, California Marin Cancer Care, Inc. Not yet recruiting Greenbrae, California, United States, 94904 San Diego Clinical Trials Not yet recruiting San Diego, California, United States, 92120 United States, Colorado The Urology Center of Colorado Recruiting Denver, Colorado, United States, 80211 United States, Nebraska GU Research Network/Urology Cancer Center Recruiting Omaha, Nebraska, United States, 68130 United States, New Jersey New Jersey Urology, LLC Not yet recruiting Voorhees, New Jersey, United States, 08043 United States, New York Premier Medical Group of the Hudson Valley PC Not yet recruiting Poughkeepsie, New York, United States, 12601 Associated Medical Professionals of New York, PLLC Not yet recruiting Syracuse, New York, United States, 13210 United States, Ohio TriState urologic Services PSC Inc., dba The Urology Group Not yet recruiting Cincinnati, Ohio, United States, 45212 United States, South Carolina Carolina Urologic Research Center Recruiting Myrtle Beach, South Carolina, United States, 29572 United States, Tennessee Urology Associates P.C. Not yet recruiting Nashville, Tennessee, United States, 37209 United States, Utah University of Utah, Huntsman Cancer Hospital Recruiting Salt Lake City, Utah, United States, 84112 University of Utah, Huntsman Cancer Institute Recruiting Salt Lake City, Utah, United States, 84112 Collapse << |
NCT02537561 | Solid Tumors ... more >>Carcinoma, Non-Small Cell Lung Non-Small Cell Lung Cancer Non-Small-Cell Lung Carcinoma Nonsmall Cell Lung Cancer Collapse << | Phase 1 | Withdrawn(The pharmaceutical c... more >>ompany did not want to follow through with support for the study.) Collapse << | December 2018 | - |
NCT03565991 | Locally Advanced or Metastatic... more >> Solid Tumors Genes, BRCA 1 Collapse << | Phase 2 | Recruiting | December 2, 2022 | - |
NCT01989546 | Advanced Ovarian Cancer ... more >> Primary Peritoneal Cancer Advanced Breast Cancer Advanced Solid Tumors Collapse << | Phase 1 Phase 2 | Recruiting | August 6, 2019 | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Recruiting Bethesda, Maryland, United States, 20892 Contact: For more information at the NIH Clinical Center contact National Cancer Institute Referral Office 888-624-1937 Collapse << |
NCT03343054 | Neoplasms | Phase 1 | Recruiting | March 3, 2019 | Japan ... more >> National Cancer Center Hospital East Recruiting Kashiwa, Chiba, Japan, 277-8577 Collapse << |
NCT01945775 | Breast Neoplasms ... more >> BRCA 1 Gene Mutation BRCA 2 Gene Mutation Collapse << | Phase 3 | Active, not recruiting | September 22, 2019 | - |
NCT02836028 | Ovarian Cancer | Phase 2 | Withdrawn | - | - |
NCT01945775 | - | - | Active, not recruiting | - | - |
NCT02316834 | Fallopian Tube Serous Adenocar... more >>cinoma High Grade Ovarian Serous Adenocarcinoma Ovarian Mass Primary Peritoneal Serous Adenocarcinoma Stage III Fallopian Tube Cancer AJCC v7 Stage III Ovarian Cancer AJCC v6 and v7 Stage III Primary Peritoneal Cancer AJCC v7 Stage IIIA Fallopian Tube Cancer AJCC v7 Stage IIIA Ovarian Cancer AJCC v6 and v7 Stage IIIA Primary Peritoneal Cancer AJCC v7 Stage IIIB Fallopian Tube Cancer AJCC v7 Stage IIIB Ovarian Cancer AJCC v6 and v7 Stage IIIB Primary Peritoneal Cancer AJCC v7 Stage IIIC Fallopian Tube Cancer AJCC v7 Stage IIIC Ovarian Cancer AJCC v6 and v7 Stage IIIC Primary Peritoneal Cancer AJCC v7 Stage IV Fallopian Tube Cancer AJCC v6 and v7 Stage IV Ovarian Cancer AJCC v6 and v7 Stage IV Primary Peritoneal Cancer AJCC v7 Collapse << | Early Phase 1 | Active, not recruiting | June 1, 2020 | United States, Texas ... more >> M D Anderson Cancer Center Houston, Texas, United States, 77030 The Woman's Hospital of Texas Houston, Texas, United States, 77054 MD Anderson Regional Care Center-Katy Houston, Texas, United States, 77094 MD Anderson Regional Care Center-Bay Area Nassau Bay, Texas, United States, 77058 MD Anderson Regional Care Center-Sugar Land Sugar Land, Texas, United States, 77478 MD Anderson Regional Care Center-The Woodlands The Woodlands, Texas, United States, 77384 Collapse << |
NCT02116777 | Adult Solid Neoplasm ... more >> Childhood Solid Neoplasm Recurrent Adult Acute Lymphoblastic Leukemia Recurrent Childhood Acute Lymphoblastic Leukemia Recurrent Childhood Central Nervous System Neoplasm Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor Recurrent Malignant Solid Neoplasm Refractory Central Nervous System Neoplasm Collapse << | Phase 1 Phase 2 | Active, not recruiting | - | - |
NCT02317874 | Advanced Malignant Solid Neopl... more >>asm BRCA Rearrangement BRCA1 Gene Mutation BRCA2 Gene Mutation Deleterious BRCA1 Gene Mutation Deleterious BRCA2 Gene Mutation Metastatic Malignant Solid Neoplasm Unresectable Solid Neoplasm Collapse << | Phase 1 | Recruiting | - | United States, New Jersey ... more >> Rutgers Cancer Institute of New Jersey Recruiting New Brunswick, New Jersey, United States, 08903 Contact: Site Public Contact 732-235-8675 Principal Investigator: Nancy Chan United States, Ohio Ohio State University Comprehensive Cancer Center Recruiting Columbus, Ohio, United States, 43210 Contact: Site Public Contact 800-293-5066 Jamesline@osumc.edu Principal Investigator: Robert Wesolowski United States, Wisconsin University of Wisconsin Hospital and Clinics Recruiting Madison, Wisconsin, United States, 53792 Contact: Site Public Contact 800-622-8922 Principal Investigator: Kari B. Wisinski Collapse << |
NCT02326844 | Ovarian Cancer | Phase 2 | Terminated(Study was closed by... more >> the Cancer Therapy Evaluation Program (CTEP)) Collapse << | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
NCT03499353 | Early Breast Cancer | Phase 2 | Recruiting | December 1, 2023 | - |
NCT02326844 | - | - | Terminated(Study was closed by... more >> the Cancer Therapy Evaluation Program (CTEP)) Collapse << | - | - |
NCT02392793 | Childhood Solid Tumors | Phase 1 | Recruiting | March 2020 | United States, Tennessee ... more >> St. Jude Children's Research Hospital Recruiting Memphis, Tennessee, United States, 38105 Contact: Sara M. Federico, MD 866-278-5833 referralinfo@stjude.org Principal Investigator: Sara M. Federico, MD Collapse << |
NCT02997176 | Advanced Solid Tumors | Phase 1 | Recruiting | May 27, 2020 | United States, California ... more >> UCLA Hematology/Oncology - Alhambra Recruiting Alhambra, California, United States, 91801 CBCC Global Research, Inc. at Comprehensive Blood and Cancer Center Recruiting Bakersfield, California, United States, 93309 St. Jude Hospital Yorba Linda DBA St. Joseph Heritage Healthcare Recruiting Fullerton, California, United States, 92835 UCLA West Medical Pharmacy, Attn: Steven L. Wong, Pharm.D. Recruiting Los Angeles, California, United States, 90095-7349 Ronald Reagan UCLA Medical Center, Drug Information Center Recruiting Los Angeles, California, United States, 90095 TRIO-US Central Administration Recruiting Los Angeles, California, United States, 90095 UCLA Hematology/Oncology Recruiting Los Angeles, California, United States, 90095 UCLA West Medical Pharmacy, Attn: Steven L. Wong, Pharm.D. Recruiting Los Angeles, California, United States, 90095 UCLA Hematology/Oncology - Porter Ranch Recruiting Porter Ranch, California, United States, 91326 UCLA Hematology/Oncology - Santa Monica Recruiting Santa Monica, California, United States, 90404 UCLA Torrance Oncology Recruiting Torrance, California, United States, 90505 UCLA Hematology/Oncology - Santa Clarita Recruiting Valencia, California, United States, 91355 United States, Florida Orlando Health, Inc. Recruiting Orlando, Florida, United States, 32806 United States, Massachusetts Brigham and Women's Hospital Not yet recruiting Boston, Massachusetts, United States, 02215 Dana-Farber Cancer Institute Not yet recruiting Boston, Massachusetts, United States, 02215 United States, Texas The University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Collapse << |
NCT02997163 | Advanced Solid Tumors | Phase 1 | Recruiting | May 24, 2019 | United States, California ... more >> Intertek USA, Inc. Recruiting San Diego, California, United States, 92121 United States, Indiana Fort Wayne Medical Oncology and Hematology, Inc. Recruiting Fort Wayne, Indiana, United States, 46804 Fort Wayne Medical Oncology and Hematology, Inc. Recruiting Fort Wayne, Indiana, United States, 46845 United States, Massachusetts Brigham and Women's Hospital Recruiting Boston, Massachusetts, United States, 02115 Dana-Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 United States, Michigan Karmanos Cancer Institute Recruiting Detroit, Michigan, United States, 48201 Karmanos Cancer Institute Weisberg Cancer Treatment Center Recruiting Farmington Hills, Michigan, United States, 48334 United States, Missouri Barnes-Jewish Hospital Recruiting Saint Louis, Missouri, United States, 63110 Washington University Infusion Center Pharmacy Recruiting Saint Louis, Missouri, United States, 63110 Washington University School of Medicine Recruiting Saint Louis, Missouri, United States, 63110 United States, New Jersey Rutgers Cancer Institute of New Jersey Recruiting New Brunswick, New Jersey, United States, 08901 United States, Texas The University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Canada, Alberta Cross Cancer Institute Recruiting Edmonton, Alberta, Canada, T6G 1Z2 Canada, Ontario Juravinski Cancer Centre Recruiting Hamilton, Ontario, Canada, L8V 5C2 Canada, Quebec Jewish General Hospital Recruiting Montreal, Quebec, Canada, H3T 1E2 Collapse << |
NCT02878785 | Acute Myeloid Leukemia | Phase 1 Phase 2 | Recruiting | December 2022 | United States, Maryland ... more >> University of Maryland Greenebaum Comprehensive Cancer Center Recruiting Baltimore, Maryland, United States, 21201 Contact: Sunita Philip, MPH, CCRP 410-328-8199 sphilip1@umm.edu Contact: Gary Saum 410-328-1180 gary.saum@umm.edu Principal Investigator: Maria Baer, MD Collapse << |
NCT03672773 | Recurrent Extensive Stage Smal... more >>l Cell Lung Carcinoma Refractory Extensive Stage Small Cell Lung Carcinoma Collapse << | Phase 2 | Not yet recruiting | November 1, 2020 | United States, California ... more >> UCLA / Jonsson Comprehensive Cancer Center Not yet recruiting Los Angeles, California, United States, 90095 Contact: Jonathan W. Goldman 310-633-8400 jwgoldman@mednet.ucla.edu Principal Investigator: Jonathan W. Goldman Collapse << |
NCT02401347 | Advanced Breast Cancer ... more >> HER2/Neu Negative Triple-Negative Breast Cancer Collapse << | Phase 2 | Recruiting | August 2019 | United States, California ... more >> Stanford University Hospitals and Clinics Recruiting Stanford, California, United States, 94305 Contact: Pei Jen Chang 650-725-0866 peijenc@stanford.edu Principal Investigator: Melinda L. Telli, M.D. Collapse << |
NCT03042910 | Solid Tumor | Phase 1 | Completed | - | United States, California ... more >> CBCC Global Research, Inc. at Comprehensive Blood and Cancer Center Bakersfield, California, United States, 93309 UCLA Hematology/Oncology - Burbank Burbank, California, United States, 91505 St. Jude Hospital Yorba Linda DBA St. Joseph Heritage Healthcare Fullerton, California, United States, 92835 UCLA West Medical Pharmacy, Attn: Steven L. Wong, Pharm.D. Los Angeles, California, United States, 90095-7349 Ronald Reagan UCLA Medical Center, Drug Information Center Los Angeles, California, United States, 90095 TRIO-US Central Administration Los Angeles, California, United States, 90095 UCLA Hematology/Oncology Los Angeles, California, United States, 90095 UCLA West Medical Pharmacy. Attn: Steven L. Wong, Pharm.D. Los Angeles, California, United States, 90095 UCLA Hematology/Oncology - Pasadena Pasadena, California, United States, 91105 UCLA Hematology/Oncology - Porter Ranch Porter Ranch, California, United States, 91326 Torrance Health Association, DBA Torrance Memorial Physician Network/Cancer Care Associates Redondo Beach, California, United States, 90277 UCLA Hematology/Oncology - Santa Monica Santa Monica, California, United States, 90404 UCLA Hematology/Oncology - Santa Clarita Valencia, California, United States, 91355 United States, Florida Memorial Cancer Institute at Memorial Regional Hospital Hollywood, Florida, United States, 33021 Memorial Regional Hospital Hollywood, Florida, United States, 33021 Orlando Health, Inc. Orlando, Florida, United States, 32806 Memorial Hospital West Pembroke Pines, Florida, United States, 33028 United States, Indiana Fort Wayne Medical Oncology and Hematology, Inc. Fort Wayne, Indiana, United States, 46804 Fort Wayne Medical Oncology and Hematology, Inc. Fort Wayne, Indiana, United States, 46845 Collapse << |
NCT01286987 | Advanced or Recurrent Solid Tu... more >>mors Breast Neoplasms Ovarian Cancer, Epithelial Ewing Sarcoma Small Cell Lung Carcinoma Prostate Cancer Pancreas Cancer Collapse << | Phase 1 | Completed | - | United States, Arizona ... more >> Scottsdale Healthcare Scottsdale, Arizona, United States, 85258 Virginia G. Piper Cancer Center Research Pharmacy Scottsdale, Arizona, United States, 85258 United States, California (IRB# 12-000131) Ronald Reagan UCLA Medical Center, Drug Information Center Los Angeles, California, United States, 90095 Ronald Reagan UCLA Medical Center Los Angeles, California, United States, 90095 UCLA Hematology/Oncology Los Angeles, California, United States, 90095 Westwood Bowyer Clinic, Peter Morton Medical Building Los Angeles, California, United States, 90095 Santa Monica - UCLA Medical Center & Orthopaedic Hospital Santa Monica, California, United States, 90404 UCLA Hematology/Oncology - Santa Monica Santa Monica, California, United States, 90404 United States, Indiana IU Health Bloomington Hospital Bloomington, Indiana, United States, 47403 Indiana University Health Melvin and Bren Simon Cancer Center Indianapolis, Indiana, United States, 46202 Investigational Drug Services Indianapolis, Indiana, United States, 46202 IU Health University Hospital Indianapolis, Indiana, United States, 46202 United States, Michigan University of Michigan Health Systems Ann Arbor, Michigan, United States, 48109 United States, Texas The University of Texas MD Anderson Cancer Center, Investigational Pharmacy Services Houston, Texas, United States, 77030-4009 United Kingdom Royal Marsden Hospital NHS Foundation Trust Sutton, Surrey, United Kingdom, SM2 5PT Collapse << |
NCT02034916 | Breast Neoplasms ... more >> BRCA 1 Gene Mutation BRCA 2 Gene Mutation Collapse << | Phase 2 | Completed | - | - |
NCT01399840 | Acute Myeloid Leukemia ... more >> Myelodysplastic Syndrome Chronic Lymphocytic Leukemia Mantle Cell Lymphoma Collapse << | Phase 1 | Completed | - | United States, Indiana ... more >> Indiana University Simon Cancer Center Indianapolis, Indiana, United States, 46202 United States, Washington Seattle Cancer Care Alliance Seattle, Washington, United States, 98109-1023 United States, Wisconsin University of Wisconsin Madison, Wisconsin, United States, 53715 United Kingdom University College London London, United Kingdom, NW1 2BU King's College Hospital London, United Kingdom, SE5 9RS The Christie NHS Foundation Manchester, United Kingdom, M20 4BX University of Newcastle Upon Tyne, NHS Foundation Trust Newcastle upon Tyne, United Kingdom, NE1 7RU Collapse << |
NCT02034916 | - | - | Completed | - | - |
NCT03070548 | Advanced Solid Tumors | Phase 1 | Completed | - | Hungary ... more >> PRA Magyarorszag Kft, Fazis I-es Klinikai Farmakologiai Vizsgalohely Budapest, Hungary, 1077 Collapse << |
NCT03070548 | - | - | Completed | - | - |
NCT02627430 | Adult Solid Neoplasm ... more >> Estrogen Receptor Negative Fallopian Tube Serous Neoplasm HER2/Neu Negative Ovarian Serous Adenocarcinoma Ovarian Serous Tumor Primary Peritoneal Serous Adenocarcinoma Progesterone Receptor Negative Recurrent Breast Carcinoma Recurrent Fallopian Tube Carcinoma Recurrent Ovarian Carcinoma Recurrent Primary Peritoneal Carcinoma Triple-Negative Breast Carcinoma Collapse << | Phase 1 | Withdrawn(Other - Protocol mov... more >>ed to Withdrawn) Collapse << | - | - |
NCT02049593 | Metastatic Cancer ... more >> Unspecified Adult Solid Tumor Collapse << | Phase 1 | Active, not recruiting | June 30, 2019 | United States, California ... more >> Jonsson Comprehensive Cancer Center Los Angeles, California, United States, 90095 Collapse << |
NCT02127151 | Endometrial Cancer | Phase 2 | Withdrawn(Withdrawal of Indust... more >>ry support for the study) Collapse << | - | United Kingdom ... more >> Royal Sussex County Hospital Brighton, East Sussex, United Kingdom, BN2 5BE The Beatson West of Scotland Cancer Centre Glasgow, Greater Glasgow, United Kingdom, G12 0YN St Bartholomew's Hospital London, Greater London, United Kingdom, EC1A 7BE University College Hospital London, Greater London, United Kingdom, NW1 2BU The Christie Hospital Manchester, Greater Manchester, United Kingdom, M20 4BX Western General Hospital Edinburgh, Lothian, United Kingdom, EH4 2XU The Churchill Hospital Oxford, Oxfordshire, United Kingdom, OX3 7LE Velindre Cancer Centre Cardiff, South Glamorgan, United Kingdom, CF14 2TL St James's University Hospital Leeds, South Yorkshire, United Kingdom, LS9 7TF Royal Marsden Hospital (Sutton) Sutton, Surrey, United Kingdom, SM2 5PT The Clatterbridge Cancer Centre Bebington, Wirral, United Kingdom, CH63 4JY Bristol Haematology and Oncology Centre Bristol, United Kingdom, BS2 8ED East Kent Hospitals University NHS Foundation Trust Kent, United Kingdom The Royal Marsden Hospital (London and Surrey) London and Surrey, United Kingdom Guy's Hospital London, United Kingdom, SE1 9RT Northern Centre for Cancer Care Newcastle, United Kingdom, NE7 7DN Collapse << |
NCT03377556 | ATM Gene Mutation ... more >> ATR Gene Mutation BARD1 Gene Mutation BRCA1 Gene Mutation BRCA2 Gene Mutation BRIP1 Gene Mutation CHEK1 Gene Mutation CHEK2 Gene Mutation FANCA Gene Mutation FANCC Gene Mutation FANCD2 Gene Mutation FANCF Gene Mutation FANCM Gene Mutation NBN Gene Mutation PALB2 Gene Mutation RAD51 Gene Mutation RAD51B Gene Mutation RAD54L Gene Mutation Recurrent Squamous Cell Lung Carcinoma RPA1 Gene Mutation Stage IV Squamous Cell Lung Carcinoma AJCC v7 Collapse << | Phase 2 | Recruiting | December 2024 | - |
NCT02567396 | Estrogen Receptor Negative ... more >> Head and Neck Squamous Cell Carcinoma HER2/Neu Negative Hormone-Resistant Prostate Cancer Metastatic Pancreatic Adenocarcinoma Progesterone Receptor Negative Solid Neoplasm Stage III Mesothelioma Stage IIIA Gastric Cancer Stage IIIA Non-Small Cell Lung Cancer Stage IIIA Ovarian Cancer Stage IIIA Small Cell Lung Carcinoma Stage IIIB Gastric Cancer Stage IIIB Non-Small Cell Lung Cancer Stage IIIB Ovarian Cancer Stage IIIB Small Cell Lung Carcinoma Stage IIIC Gastric Cancer Stage IIIC Ovarian Cancer Stage IV Mesothelioma Stage IV Non-Small Cell Lung Cancer Stage IV Ovarian Cancer Stage IV Small Cell Lung Carcinoma Triple-Negative Breast Carcinoma Collapse << | Phase 1 | Withdrawn(Other- Protocol move... more >>d to Disapproved) Collapse << | - | - |
NCT02358200 | Triple Negative Metastatic Bre... more >>ast Cancer BRCA-mutated Solid Tumor Collapse << | Phase 1 | Active, not recruiting | June 2020 | United States, California ... more >> University of California San Francisco San Francisco, California, United States, 94115 Collapse << |
NCT02282345 | Breast Cancer | Phase 2 | Active, not recruiting | April 2020 | United States, Texas ... more >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
NCT02286687 | Advanced Cancers | Phase 2 | Recruiting | December 22, 2020 | United States, Texas ... more >> University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Collapse << |
NCT03426254 | Advanced or Recurrent Solid Tu... more >>mors Breast Neoplasm Collapse << | Phase 1 | Enrolling by invitation | February 2019 | Switzerland ... more >> BioGene Pharmaceutical Zürich, ZH, Switzerland, 8091 Collapse << |
NCT01776437 | Human Volunteers | Phase 1 | Completed | - | United States, Indiana ... more >> Covance Clinical Research Unit Inc. Evansville, Indiana, United States, 47710 Collapse << |
靶点 | Description | IC50 |
---|---|---|
PARP1 | IC50:0.57nM |
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