CAS No.: 1373431-65-2
Talazoparib tosylate/他拉唑帕利甲苯磺酸盐 Catalog No. CSN26456
Synonyms: BMN 673ts;BMN-673;LT-673
Talazoparib, also known as BMN-673 and MDV-3800, is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity (PARP1 IC50 = 0.57 nmol/L). Talazoparib acts as an inhibitor of poly ADP ribose polymerase(PARP) which aids in single strand DNA repair. Cells that have BRCA1/2 mutations are susceptible to the cytotoxic effects of PARP inhibitors because of an accumulation of DNA damage. Talazoparib is theorized to have a higher potency than olaparib due to the additional mechanism of action called PARP trapping. PARP trapping is the mechanism of action where the PARP molecule is trapped on the DNA, which interferes with the cells ability to replicate. Talazoparib is found to be ~100 fold more efficient in PARP trapping than olaparib.
| 规格 | 价格 | 促销价格 | 库存 | 数量 |
|---|
400-920-2911
sales@csnpharm.cn
tech@csnpharm.cn靶点选择性
生物活性
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1373431-65-2 | 储存条件 |
|
|
| 分子式 | C26H22F2N6O4S | 运输 | 蓝冰 | |
| 分子量 | 552.55 | 别名 | BMN 673ts;BMN-673;LT-673;MDV-3800;Talazoparib;Talzenna |
