|(6S,9S,12S,15S,18S)-1,6-二氨基-9-(4-氨基丁基)-12-(羧甲基)-18-(4-羟基苄基)-1-亚氨基-15-异丙基-7,10,13,16-四氧-2,8,11,14,17-五杂氮杂壬烷-19-油酸|CsnPharm

CAS No.: 69558-55-0

Thymopentin/胸腺五肽 Catalog No. CSN22564

Synonyms: TP5;RKDVY;Thymopoietin II (32-36)

Thymopentin is an immunomodulatory peptide and an immunostimulant which can enhance the production of thymic T cells and may help restore immunocompetence in immunosuppressed subjects.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Thymopentin is a biologically active peptide secreted mainly by the epithelial cells of thymic cortex and medulla. Thymopentin is an effective immunomodulatory agent with a short plasma half-life of 30 seconds. Thymopentin enhances the generation of T-cell lineage derived from human embryonic stem cells (hESCs). Thymopentin enhances T-cell lineage differentiation from hESCs in vitro by mimicking thymus peptide environment in vivo^[1]. Thymopentin (TP5), a synthetic immunomodulator pentapeptide (Arg-Lys-Asp-Val-Tyr) with an excellent safety profile in the clinic, protects mice against cecal ligation and puncture (CLP)-induced sepsis, as shown by improved survival rate, decreased level of pro-inflammatory cytokines and reduced ratios of macrophages and neutrophils in spleen and peritoneum^[2]. TP5 (Thymopentin) exerts a protective effect on DSS(Dextran sulfate sodium)-induced colitis by triggering the production of IL-22 in both innate and adaptive lymphocytes^[3].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02686554	-	-	Recruiting	December 2019	Germany ... more >> Charité University Medicine Recruiting Berlin, Germany, 10117 Contact: Oliver Peters, MD +4930450517628 oliver.peters@charite.de Collapse <<
NCT00865501	Primary Hypertension	Phase 3	Completed	-	Germany ... more >> University Erlangen-Nürnberg, Nephrology and Hypertension Erlangen, Germany, 91054 Collapse <<
NCT00138944	Essential Hypertension	Phase 3	Completed	-	Germany ... more >> CRC Medical Department IV Erlangen, Germany, 91054 Collapse <<

更多
参考文献

[1] Zhu MX, Wan WL, Li HS, Wang J, Chen GA, Ke XY. Thymopentin enhances the generation of T-cell lineage derived from human embryonic stem cells in vitro. Exp Cell Res. 2015 Feb 15;331(2):387-98
[2] Zhang Y, Yang X, Yan W, Li R, Ye Q, You L, Xie W, Mo K, Fu R, Wang Y, Chen Y, Hou H, Yang Y, Birnbaumer L, Di Q, Li X. Thymopentin improves the survival of septic mice by promoting the production of 15-deoxy-prostaglandin J2 and activating the PPARγ signaling pathway. FASEB J. 2020 Sep;34(9):11772-11785
[3] Cao Q, Gao X, Lin Y, Yue C, Wang Y, Quan F, Zhang Z, Liu X, Lu Y, Zhan Y, Yang H, Li X, Qin D, Birnbaumer L, Hao K, Yang Y. Thymopentin ameliorates dextran sulfate sodium-induced colitis by triggering the production of IL-22 in both innate and adaptive lymphocytes. Theranostics. 2019 Oct 12;9(25):7490-7505

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.4711 mL
- 7.3555 mL
- 14.7110 mL
- 5 mM
- 0.2942 mL
- 1.4711 mL
- 2.9422 mL
- 10 mM
- 0.1471 mL
- 0.7355 mL
- 1.4711 mL

技术信息

CAS号

69558-55-0

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C30H49N9O9

运输

蓝冰

分子量

679.77

别名

TP5;RKDVY;Thymopoietin II (32-36);Thymopoietin Pentapeptide;ORF-15244;ORF 15244 ORF15244;TP 5 Thymopoietin pentapeptide;胸腺五肽

溶解度

DMSO	98.0 mg/mL (144.2 mM)
Water	98.0 mg/mL (144.2 mM)
Ethanol	Insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02686554	-	-	Recruiting	December 2019	Germany ... more >> Charité University Medicine Recruiting Berlin, Germany, 10117 Contact: Oliver Peters, MD +4930450517628 oliver.peters@charite.de Collapse <<
NCT00865501	Primary Hypertension	Phase 3	Completed	-	Germany ... more >> University Erlangen-Nürnberg, Nephrology and Hypertension Erlangen, Germany, 91054 Collapse <<
NCT00138944	Essential Hypertension	Phase 3	Completed	-	Germany ... more >> CRC Medical Department IV Erlangen, Germany, 91054 Collapse <<
NCT00002109	HIV Infections	Phase 3	Completed	-	-
NCT00002049	HIV Infections	Not Applicable	Completed	-	United States, New Jersey ... more >> Immunobiology Research Institute Annandale, New Jersey, United States, 088010999 Collapse <<
NCT00002332	HIV Infections	Phase 2	Completed	-	United States, California ... more >> Dr Marcus Conant San Francisco, California, United States, 94115 Dr Jeffrey Galpin Tarzana, California, United States, 91356 United States, Pennsylvania Novum Inc Pittsburgh, Pennsylvania, United States, 15206 Collapse <<
NCT00002051	HIV Infections	Not Applicable	Completed	-	United States, New Jersey ... more >> Immunobiology Research Institute Annandale, New Jersey, United States, 088010999 Collapse <<
NCT00460681	Hepatocellular Carcinoma	Phase 3	Unknown	February 2012	China, Shanghai ... more >> Liver Cancer Institute and Zhongshan Hospital, Fudan University Recruiting Shanghai, Shanghai, China, 200032 Contact: S J Qiu, MD +86-21-64037181 qiusj68@zshospital.com Collapse <<
NCT00002050	HIV Infections	Not Applicable	Completed	-	United States, New Jersey ... more >> Immunobiology Research Institute Annandale, New Jersey, United States, 088010999 Collapse <<
NCT00002066	HIV Infections	Not Applicable	Completed	-	United States, New Jersey ... more >> Immunobiology Research Institute Annandale, New Jersey, United States, 088010999 Collapse <<
NCT00002289	HIV Infections	Not Applicable	Completed	-	United States, New Jersey ... more >> Immunobiology Research Institute Annandale, New Jersey, United States, 088010999 Collapse <<

Thymopentin/胸腺五肽 Catalog No. CSN22564

靶点选择性

请登录您的专属账户

确认信息