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CAS No.: 27591-69-1

Tilorone 2HCl/替洛隆二盐酸盐 Catalog No. CSN12094

Synonyms: Tilorone (hydrochloride);NSC 143969;DEAE-F

Tilorone 2HCl is an orally active interferon inducer, used as an antiviral drug.

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生物活性

实验方案

技术信息

生物活性

描述Tilorone dihydrochloride (tilorone) is a small-molecule, orally bioavailable drug. Tilorone was shown to have 52% human plasma protein binding with excellent plasma stability and a mouse liver microsome half-life of 48 min. Dose range-finding studies in mice demonstrated a maximum tolerated single dose of 100 mg/kg of body weight. Tilorone doses of 25 and 50 mg/kg proved efficacious in protecting 90% of mice from a lethal challenge with mouse-adapted with once-daily intraperitoneal (i.p.) dosing for 8 days^[3]. RT-PCR analysis showed that tilorone dihydrochloride induced upregulation and downregulation in expression of Bax and Bcl-2, respectively^[4]. Furthermore, the synthesized tilorone dihydrochloride exhibited an obvious effect on induction of interferon-α (IFN-α) in mice within 12 h, and the peak level was observed until 24 h^[5]. Moreover, tilorone treatment resulted in decreased PC3 cell growth and invasion; PC3 cells with inactive CDK5 (Cyclin-dependent kinase 5) were inhibited more effectively^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0684 mL
- 10.3419 mL
- 20.6838 mL
- 5 mM
- 0.4137 mL
- 2.0684 mL
- 4.1368 mL
- 10 mM
- 0.2068 mL
- 1.0342 mL
- 2.0684 mL

技术信息

CAS号

27591-69-1

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C25H36Cl2N2O3

运输

蓝冰

分子量

483.47

别名

Tilorone (hydrochloride);NSC 143969;DEAE-F;Tilorone Dihydrochloride;盐酸替洛隆;梯洛龙二盐酸盐;替洛隆二盐酸盐;盐酸梯洛龙

溶解度

DMSO	43.0 mg/mL (88.9 mM)
Ethanol	96.0 mg/mL (198.6 mM)

动物实验配方

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Tilorone 2HCl/替洛隆 二盐酸盐 Catalog No. CSN12094

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Tilorone 2HCl/替洛隆二盐酸盐 Catalog No. CSN12094