生物活性

• 描述Tofogliflozin is a potent and highly specific sodium/glucose cotransporter 2 (SGLT2) inhibitor with Ki values of 2.9, 14.9, and 6.4 nM for human, rat, and mouse SGLT2.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT02284269	-	-	Active, not recruiting	-	-
  NCT02528019	Effects of the DPP-4 Inhibitor... more >>s or SGLT2 Inhibitors on the Protective Actions for Diabetic Complications Collapse <<	Phase 4	Unknown	August 2018	Japan ... more >> Kurume University Hospital Recruiting Kurume city, Japan, 830-0011 Contact: Nobuhiro Tahara, MD, PhD    +81-942-31-7580    ntahara@med.kurume-u.ac.jp    Contact: Sho-ichi Yamagishi, MD, PhD    +81-942-31-7562       Principal Investigator: Nobuhiro Tahara, MD, PhD Collapse <<
  NCT02201004	Type 2 Diabetes Mellitus	Phase 4	Completed	-	Japan ... more >> Investigational Site Number 392-028 Adachi-ku, Japan Investigational Site Number 392-007 Atsugi-shi, Japan Investigational Site Number 392-026 Chuoh-ku, Japan Investigational Site Number 392-021 Fukuoka-shi, Japan Investigational Site Number 392-002 Ichihara-shi, Japan Investigational Site Number 392-012 Iruma-shi, Japan Investigational Site Number 392-003 Kawaguchi-shi, Japan Investigational Site Number 392-014 Kitakyusyu-shi, Japan Investigational Site Number 392-027 Kobe-shi, Japan Investigational Site Number 392-004 Koga-shi, Japan Investigational Site Number 392-022 Kunitachi-shi, Japan Investigational Site Number 392-019 Kurume-shi, Japan Investigational Site Number 392-001 Kyoto-shi, Japan Investigational Site Number 392-024 Kyoto-shi, Japan Investigational Site Number 392-006 Matsudo-shi, Japan Investigational Site Number 392-008 Mito-shi, Japan Investigational Site Number 392-030 Musashino-shi, Japan Investigational Site Number 392-029 Okayama-shi, Japan Investigational Site Number 392-017 Otsu-shi, Japan Investigational Site Number 392-011 Sagamihara-shi, Japan Investigational Site Number 392-020 Sakai-shi, Japan Investigational Site Number 392-010 Sapporo-shi, Japan Investigational Site Number 392-016 Sendai-shi, Japan Investigational Site Number 392-018 Shinjuku-ku, Japan Investigational Site Number 392-005 Shizuoka-shi, Japan Investigational Site Number 392-031 Suita-shi, Japan Investigational Site Number 392-015 Sumida-ku, Japan Investigational Site Number 392-023 Sunto-gun, Japan Investigational Site Number 392-013 Tokorozawa-shi, Japan Investigational Site Number 392-025 Yokohama-shi, Japan Collapse <<

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• 参考文献

• [1] Nagata T, Fukuzawa T, et al. Tofogliflozin, a novel sodium-glucose co-transporter 2 inhibitor, improves renal and pancreatic function in db/db mice. Br J Pharmacol. 2013 Oct;170(3):519-31.

  [2] Suzuki M, Honda K, et al. Tofogliflozin, a potent and highly specific sodium/glucose cotransporter 2 inhibitor, improves glycemic control in diabetic rats and mice. J Pharmacol Exp Ther. 2012 Jun;341(3):692-701.