TPI-1 | Tyrosine Phosphatase Inhibitor 1 | SHP-1 Inhibitor

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TPI-1 99%+

货号：A373292 同义名： Tyrosine Phosphatase Inhibitor 1 产品仅供科研

TPI-1 is a protein tyrosine phosphatase inhibitor with IC50 of 40nM increased SHP1 phospho-substrates (pLck-pY394, pZap70 and pSlp76) in Jurkat T cells but had little effects on pERK1/2 or pLck-pY505 regulated by phosphatases SHP2 or CD45, respectively. TPI-1 was shown to be more effective than sodium stibogluconate in SHP1 inhibition, immune cell activation and anti-tumor action.

TPI-1 化学结构
CAS号：79756-69-7

TPI-1 3D分子结构
CAS号：79756-69-7

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TPI-1 纯度/质量文件

货号：A373292 标准纯度：99%+ 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Mar. Drugs, 2024, 22(5): 194. Ambeed. [ A104599 ]; • Pharmaceuticals, 2024, 17(5): 570. Ambeed. [ A224421 ]; 更多 >

TPI-1 生物活性

描述

TPI-1 is a selective SHP-1 inhibitor with IC50 value of 40nM. It dose-dependently increased SHP-1 phospho-substrates (pLck-pY394, pZap70, and pSlp76) in Jurkat T cells at concentration<3μg/ml but had little effects on p-ERK1/2 or pLck-pY505 regulated by phosphatases SHP-2 or CD45, respectively. TPI-1 induced both mouse splenic-IFN-γ⁺ cells and IFN-γ⁺ cells in human peripheral blood in vitro. Significantly, TPI-1 inhibited the growth of B16 melanoma tumors in mice by 83% (but not in athymic nude mice with T cell deficiency) at a tolerated oral dose in a T cell-dependent manner but had little effects on B16 cell growth in culture. TPI-1 also inhibited B16 tumor growth and prolonged tumor mice survival as a tolerated s.c. agent^[2].

TPI-1 动物研究

Dose	Mice: 1 mg/kg - 10 mg/kg^[1] (s.c.)
Administration	s.c.

TPI-1 参考文献

[1]Kundu S, Fan K, et al. Novel SHP-1 inhibitors tyrosine phosphatase inhibitor-1 and analogs with preclinical anti-tumor activities as tolerated oral agents. J Immunol. 2010 Jun 1;184(11):6529-36.

[2]Kundu S, Fan K, Cao M, Lindner DJ, Zhao ZJ, Borden E, Yi T. Novel SHP-1 inhibitors tyrosine phosphatase inhibitor-1 and analogs with preclinical anti-tumor activities as tolerated oral agents. J Immunol. 2010 Jun 1;184(11):6529-36. doi: 10.4049/jimmunol.0903562. Epub 2010 Apr 26. PMID: 20421638; PMCID: PMC3049920.

TPI-1 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.95mL

0.79mL

0.40mL

19.76mL

3.95mL

1.98mL

39.51mL

7.90mL

3.95mL

TPI-1 技术信息

CAS号	79756-69-7
分子式	C₁₂H₆Cl₂O₂
分子量	253.081

别名	Tyrosine Phosphatase Inhibitor 1
运输	蓝冰

存储条件

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 50 mg/mL(197.57 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

摩尔计算器

计算溶液所需的质量，体积或浓度。 Ambeed 摩尔浓度计算器基于以下方程式：

浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)=质量 (g)

浓度

体积

分子量

质量

TPI-1 99%+

TPI-1 纯度/质量文件

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TPI-1 生物活性

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TPI-1 99%+

TPI-1 纯度/质量文件

全球学术期刊中引用的产品

TPI-1 生物活性

TPI-1 动物研究

TPI-1 参考文献

TPI-1 实验方案

TPI-1 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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