|反式-2-苯基环丙胺|CsnPharm

CAS No.: 1986-47-6

反式-2-苯基环丙胺盐酸盐 Catalog No. CSN18718

Synonyms: SKF-385 HCl;2-PCPA HCl;Tranylcypromine HCl

Tranylcypromine is a dual inhibitor of both MAO-A/B and LSD1.

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技术信息

生物活性

描述Trans-2-Phenylcyclopropylamine (2-PCPA) is a time-dependent, mechanism-based irreversible inhibitor of LSD1 with a KI of 242 mM and a kinact of 0.0106 s-1. 2-PCPA shows limited selectivity for human MAOs versus LSD1, with kinact/KI values only 16-fold and 2.4-fold higher for MAO B and MAO A, respectively^[3]. 2-PCPA-based inhibitors featuring substitutions on the amino group have emerged, with sub-micromolar affinities toward LSD1 (Lysine-specific demethylase 1) and high selectivities over monoamine oxidases (MAOs)^[4]. Mice treated with the antidepressant trans-2-phenylcyclopropylamine (2-PCPA) were protected against diet-induced-obesity, and adiposity was reversed in pre-established diet-induced obese mice. 2-PCPA can reduce obesity by decreasing food intake in the long term while increasing activity in the short-term^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.8945 mL
- 29.4724 mL
- 58.9449 mL
- 5 mM
- 1.1789 mL
- 5.8945 mL
- 11.7890 mL
- 10 mM
- 0.5894 mL
- 2.9472 mL
- 5.8945 mL

技术信息

CAS号

1986-47-6

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C9H12ClN

运输

蓝冰

分子量

169.65

别名

SKF-385 HCl;2-PCPA HCl;Tranylcypromine HCl;2-PCPA;trans-2-Phenylcyclopropylamine;2-PCPA Hydrochloride;Tranylcypromine hydochloride;SKF 385 hydrochloride

溶解度

DMSO	33.0 mg/mL (194.5 mM)
Water	32.0 mg/mL (188.6 mM)
Ethanol	32.0 mg/mL (188.6 mM)

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反式-2-苯基环丙胺盐酸盐 Catalog No. CSN18718

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