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CAS No.: 6879-01-2

TuberosteMonine trifluoroacetate/对叶百部碱三氟乙酸盐 Catalog No. CSN19928

Synonyms: 对叶百部碱;晚香玉素

Tuberostemonine is a natural product isolated from the roots of Stemona japonica, which shows therapeutic effects against cigarette smoke-induced acute lung inflammation in mice and acts as an open-channel blocker at the crayfish neuromuscular junction.

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生物活性

描述Tuberostemonine is a natural product isolated from the roots of Stemona japonica, which shows therapeutic effects against cigarette smoke-induced acute lung inflammation in mice and acts as an open-channel blocker at the crayfish neuromuscular junction. Tuberstemonine displayed the highest level of inhibition (55.4%) of diaphorase activity of PfFNR(Plasmodium falciparum)^[3]. Tuberostemonine could reverse the multidrug resistance of K562/ADR via down-regulating the expression of Nf-κB and inhibiting th1e expression of Survivin^[4]. At the crayfish neuromuscular junction, tuberostemonine, an alkaloid from Stemona japonica, reduced the amplitude of both the excitatory junctional potential (e.j.p.) and the glutamate response in a dose-dependent manner at concentrations above 0.1 mM. Tuberostemonine acted presynaptically on the crayfish neuromuscular junction to reduce a quantal content of extracellularly recorded e.j.p.s, and postsynaptically to reduce their unit size. The decay of the excitatory synaptic current was accelerated by tuberostemonine. The inhibitory action of tuberostemonine on glutamate responses was voltage-dependent and hyperpolarization increased the drug action^[5]. TS (tuberostemonine) has anti-inflammatory effects against CS(cigarette smoke)-induced acute lung inflammation^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.6631 mL
- 13.3155 mL
- 26.6310 mL
- 5 mM
- 0.5326 mL
- 2.6631 mL
- 5.3262 mL
- 10 mM
- 0.2663 mL
- 1.3316 mL
- 2.6631 mL

技术信息

CAS号	6879-01-2	储存条件	粉末 Keep in dark place,Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C22H33NO4	运输	蓝冰
分子量	375.50	别名	对叶百部碱;晚香玉素

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