153190-29-5|U-74389G|CsnPharm

CAS No.: 153190-29-5

U-74389G Catalog No. CSN20526

Synonyms: PNU74389G (meleate);Methylated Tirilazad;PNU74389G (meleate

U-74389G is an antioxidant which prevents iron-dependent lipid peroxidation. It protects against ischemia-reperfusion injury in animal heart, liver, and kidney models.

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400-920-2911

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技术信息

生物活性

描述U-74389G resides in lazaroids that are low molecular weight antioxidants. Lazaroids are deprived of glucocorticoids and mineralocorticoids in nature and act by inhibiting irondependent lipid peroxidation. Other potential mechanisms of action include oxygen-free radical-scavenging, ironchelating, and membrane-stabilizing^[3]. Sildenafil reduced TNF-α tissue levels and increased body weight. U-74389G reduced TNF-α, the macroscopic index of mucosal damage score (CMDI) and increased body weight. The combined treatment with sildenafil and U-74389G reduced tissue levels of both TNF-α and MDA, lowered CMDI and microscopic Geboes score, and increased body weight^[4]. The expression of alkaline phosphatase and bone morphogenetic protein, accompanied by the production of IL-6 and IL-8, was up-regulated in response to IL-1β and was inhibited by the addition of U-74389G. The NF-κB pathway was activated by IL-1β and involved in the suppression of U-74389G on osteoblastic differentiation in AVICs. The negative effects of U-74389G on ostengenic gene expression and mineralization of AVICs were blocked by glucocorticoid receptor antagonist mifepristone and the NF-κB inhibitor Bay 11-7082^[5]. U-74389G administration significantly decreased the predicted creatinine levels by 21.02 ± 5.06% (p = 0.0001). Reperfusion time non-significantly increased the predicted creatinine levels by 4.20 ± 6.12% (p = 0.4103). However, U-74389G administration and reperfusion time together produced a significant combined effect in decreasing the predicted creatinine levels by 11.69 ± 3.16% (p = 0.0005)^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.3757 mL
- 6.8785 mL
- 13.7570 mL
- 5 mM
- 0.2751 mL
- 1.3757 mL
- 2.7514 mL
- 10 mM
- 0.1376 mL
- 0.6878 mL
- 1.3757 mL

技术信息

CAS号	153190-29-5	储存条件	粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C41H54N6O6	运输	蓝冰
分子量	726.90	别名	PNU74389G (meleate);Methylated Tirilazad;PNU74389G (meleate

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