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CAS No.: 2271358-65-5

UAMC-3203 HCl Catalog No. CSN24079

Synonyms: UAMC-3203 (hydrochloride);UAMC-3203 HCl;UAMC-3203

UAMC-3203 HCl is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Ferroptosis is an iron-catalyzed, nonapoptotic form of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides that results in oxidative lipid damage in cell membranes. Ferroptosis is initiated by the failure of the glutathione-dependent antioxidant defenses, which can result in unchecked lipid peroxidation and eventual cell death. This form of cell death can be induced in the human body so that ferroptosis can contribute to the medical field such as in aiding in cancer treatments. UAMC-3203, as a potent ferroptosis inhibitor with IC50 of 12nM, was able to inhibit erastin-induced ferroptotic cell death. UAMC-3203 inserted itself into the lipid bilayer. The solubility-enhancing piperazine ring and the sulphonamide of UAMC-3203 engaged in hydrogen bonding interactions with the phospholipid head groups, while the lipophilic core and ring substituents interacted with the lipid tails ^[1]. This compound has a significantly improved solubility over previously published molecules. UAMC-3203 was injected intraperitoneally (20 µmol/kg) daily, over a period of 4 weeks, and no toxicity was observed in mice after repeated injections ^[1].
参考文献

[1] Devisscher L, Van Coillie S, Hofmans S, Van Rompaey D, Goossens K, Meul E, Maes L, De Winter H, Van Der Veken P, Vandenabeele P, Berghe TV, Augustyns K. Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy. J Med Chem. 2018 Nov 21;61(22):10126-10140. doi: 10.1021/acs.jmedchem.8b01299. Epub 2018 Nov 6. PMID: 30354101.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.9680 mL
- 9.8402 mL
- 19.6804 mL
- 5 mM
- 0.3936 mL
- 1.9680 mL
- 3.9361 mL
- 10 mM
- 0.1968 mL
- 0.9840 mL
- 1.9680 mL

技术信息

CAS号

2271358-65-5

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C25H38ClN5O2S

运输

蓝冰

分子量

508.12

别名

UAMC-3203 (hydrochloride);UAMC-3203 HCl;UAMC-3203

溶解度

DMSO	50.0 mg/mL (98.4 mM) warming

动物实验配方

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