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CAS No.: 1610964-64-1
Synonyms: PTC596
PTC596 is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. PTC596 targets BMI1 expressed by both tumor cells and cancer stem cells (CSCs), and induces hyper-phosphorylation of BMI1, leading to its degradation. PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells[1][2].
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技术信息
CAS号 | 1610964-64-1 | 储存条件 |
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分子式 | C19H13F5N6 | 运输 | 蓝冰 | |||||
分子量 | 420.34 | 别名 | PTC596 | |||||
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动物实验配方 |
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