CAS No.: 1144068-46-1
WYE-132 Catalog No. CSN15879
Synonyms: WYE-132WYE-132;WYE-125132
WYE-125132 is a highly potent, ATP-competitive and specific mTOR kinase inhibitor with an IC50 of 0.19 nM, highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG1 and ATR.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 细胞研究
- Cell Data
- 参考文献
- [1] Yu K, Shi C, et al. Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2. Cancer Res. 2010 Jan 15;70(2):621-31.
- [2] Shor B, Wu J, et al. Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells. J Biol Chem. 2010 May 14;285(20):15380-92.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1144068-46-1 | 储存条件 |
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| 分子式 | C27H33N7O4 | 运输 | 蓝冰 | |
| 分子量 | 519.60 | 别名 | WYE-132WYE-132;WYE-125132 |
