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CAS No.: 1311423-89-8

YF-2 Catalog No. CSN23787

YF-2 is a highly selective and blood-brain-barrier permeable histone acetyltransferase activator, it acetylates H3 in the hippocampus.

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述YF2 is a selective HAT (histone acetyltransferase) activator with EC50 values of 2.75μM, 29.04μM and 49.31μM for CBP, PCAF, and GCN5, respectively, with no effect on HDAC. YF-2 is able to cross brain blood barrier and improved memory deficit in Alzheimer's disease models. Intraperitoneal injection with 10mg/kg YF2 post 0.5h and 2h significantly increased H3 acetylation level in hippocampus. It ameliorated the contextual fear memory deficit in Aβ42-infused mice at dose of 20mg/kg. Aβ42-induced memory impairment of mice could be rescued by YF2 at dose of 5mg/kg in radial arm water maze study, ameliorated the LTP deficit in Aβ42-treated slices, ameliorated the contextual fear memory deficit in Aβ42-infused mice, improved Aβ42-induced cognitive dysfunction in water maze/reference memory test at dose of 5mg/kg or 20mg/kg. Similarly, it ameliorated the reference and contextual fear memory deficit in APP/PS1 mice at 20mg/kg, rescued the reduction in acetylated H3 levels after infusion of Aβ42 at dose of 5mg/kg. YF2 inhibited cell proliferation, including U251, NCI-ADR-RES, A549, Hs578T and CCRF-CEM cell lines, with IC50 values ranging in 8.87E-5M to 2.48E-4M.
动物研究
剂量
Mice: 20 mg/kg^[1] (p.o.)

给药途径
p.o
参考文献

动物研究
剂量	Mice: 20 mg/kg^[1] (p.o.)
给药途径	p.o

[1] WO2011072243A1

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3210 mL
- 11.6050 mL
- 23.2100 mL
- 5 mM
- 0.4642 mL
- 2.3210 mL
- 4.6420 mL
- 10 mM
- 0.2321 mL
- 1.1605 mL
- 2.3210 mL

技术信息

CAS号

1311423-89-8

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H22ClF3N2O3

运输

蓝冰

分子量

430.85

别名

溶解度

DMSO	85.0 mg/mL (197.3 mM)
Ethanol	85.0 mg/mL (197.3 mM)

动物实验配方

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