CAS No.: 1817626-54-2
Zimlovisertib Catalog No. CSN18657
Synonyms: PF-06650833;PF-6650833
PF-06650833 is an inhibitor ofInterleukin-1 receptor associated kinase 4 (IRAK4), and used to treat diseases such as rheumatoid arthritis, lupus, and lymphomas.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT02996500 Rheumatoid Arthritis Phase 2 Completed - - NCT02224651 Healthy Phase 1 Completed - United States, Connecticut ... more >> New Haven Clinical Research Unit New Haven, Connecticut, United States, 06511 Collapse << NCT02609139 Healthy Phase 1 Completed - United States, Connecticut ... more >> New Haven Clinical Research Unit New Haven, Connecticut, United States, 06511 Collapse << - 更多
- 参考文献
- [1] Seganish WM. Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015). Expert Opin Ther Pat. 2016 Aug;26(8):917-32.
- [2] Lee KL, Ambler CM, et al. Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl] methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design. J Med Chem. 2017 Jul 13;60(13):5521-5542.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1817626-54-2 | 储存条件 |
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| 分子式 | C18H20FN3O4 | 运输 | 蓝冰 | |||||||
| 分子量 | 361.37 | 别名 | PF-06650833;PF-6650833 | |||||||
| 溶解度 |
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动物实验配方 |
